TY - JOUR
T1 - Node/Aorta and Node/Liver SUV Ratios from 18F-FDG PET/CT May Improve the Detection of Occult Mediastinal Lymph Node Metastases in Patients with Non-Small Cell Lung Carcinoma
AU - Kuo, Wen Han
AU - Wu, Yi Cheng
AU - Wu, Ching Yang
AU - Ho, Kung Chu
AU - Chiu, Pin Hsiu
AU - Wang, Chih Wei
AU - Chang, Chee Jen
AU - Yu, Chih Teng
AU - Yen, Tzu Chen
AU - Lin, Chieh
PY - 2012/6
Y1 - 2012/6
N2 - Rationale and Objectives: Research suggests that the semiquantitative determination of nodal 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET)/computed tomography (CT) may be useful for the assessment of mediastinal metastases in patients with non-small-cell lung carcinoma (NSCLC). The aim of this study was to evaluate the diagnostic ability of using different standardized uptake value (SUV) parameters in the detection of ipsilateral mediastinal (N2) disease. Materials and Methods: A total of 102 patients newly diagnosed with non-small-cell lung carcinoma who underwent 18F-FDG PET/CT before surgery and had not received prior therapy were retrospectively included. All patients underwent surgical resection of the primary tumor and mediastinal lymph node dissection. On a station-based analysis, different SUV parameters (eg, mediastinal lymph node SUV, node/aorta SUV ratio, and node/liver SUV ratio) were evaluated using the histopathologic results as the reference standard. The optimal cutoff value for each SUV parameter was determined with receiver-operating characteristic curve analysis. Results: The areas under the receiver-operating characteristic curves were 0.674, 0.693, and 0.715 for node SUV, node/aorta SUV ratio, and node/liver SUV ratio, respectively (P < .05). With cutoff values of 3.15, 1.37, and 1.02 for node SUV, node/aorta SUV ratio, and node/liver SUV ratio, respectively, the sensitivity of 18F-FDG PET/CT for N2 staging was 57.1%, 85.7%, and 71.4%, and specificity was 74.2%, 50.5%, and 61.9%. Conclusions: Compared to node SUV alone, the use of node/aorta and node/liver SUV ratios resulted in improved detection of N2 metastases. The two SUV parameters may potentially improve the diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of N2 disease in patients with non-small-cell lung carcinoma.
AB - Rationale and Objectives: Research suggests that the semiquantitative determination of nodal 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET)/computed tomography (CT) may be useful for the assessment of mediastinal metastases in patients with non-small-cell lung carcinoma (NSCLC). The aim of this study was to evaluate the diagnostic ability of using different standardized uptake value (SUV) parameters in the detection of ipsilateral mediastinal (N2) disease. Materials and Methods: A total of 102 patients newly diagnosed with non-small-cell lung carcinoma who underwent 18F-FDG PET/CT before surgery and had not received prior therapy were retrospectively included. All patients underwent surgical resection of the primary tumor and mediastinal lymph node dissection. On a station-based analysis, different SUV parameters (eg, mediastinal lymph node SUV, node/aorta SUV ratio, and node/liver SUV ratio) were evaluated using the histopathologic results as the reference standard. The optimal cutoff value for each SUV parameter was determined with receiver-operating characteristic curve analysis. Results: The areas under the receiver-operating characteristic curves were 0.674, 0.693, and 0.715 for node SUV, node/aorta SUV ratio, and node/liver SUV ratio, respectively (P < .05). With cutoff values of 3.15, 1.37, and 1.02 for node SUV, node/aorta SUV ratio, and node/liver SUV ratio, respectively, the sensitivity of 18F-FDG PET/CT for N2 staging was 57.1%, 85.7%, and 71.4%, and specificity was 74.2%, 50.5%, and 61.9%. Conclusions: Compared to node SUV alone, the use of node/aorta and node/liver SUV ratios resulted in improved detection of N2 metastases. The two SUV parameters may potentially improve the diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of N2 disease in patients with non-small-cell lung carcinoma.
KW - Mediastinal lymph node
KW - Node/aorta SUV ratio
KW - Node/liver SUV ratio
KW - Non-small-cell lung cancer
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=84862792714&partnerID=8YFLogxK
U2 - 10.1016/j.acra.2012.02.013
DO - 10.1016/j.acra.2012.02.013
M3 - 文章
C2 - 22459646
AN - SCOPUS:84862792714
SN - 1076-6332
VL - 19
SP - 685
EP - 692
JO - Academic Radiology
JF - Academic Radiology
IS - 6
ER -
