Noninvasive monitoring of tumor growth in a rat glioma model: Comparison between neurological assessment and animal imaging

Ting Chung Wang, Ing Tsung Hsiao, Yu Kai Cheng, Shiaw Pyng Wey, Tzu Chen Yen, Kun Ju Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations

Abstract

Malignant gliomas are the most common primary tumors that arise from glial cells and are characterized by extensive invasiveness and rapid progression. Limitation of the current therapeutic regimen for malignant glioma warrants the development of new therapies strategies. In order to investigate new methods of therapy, establishment of a reliable animal model is essential both in studying the tumor biology and trialing a new therapeutic strategy. Noninvasive monitoring of tumor growth in living animals may be important for new therapeutic strategy development. The development of animal imaging techniques has improved our ability to investigate animal models of malignant gliomas. In this study, both neurological examination and positron emission tomography (PET) with 18F-FDG were used to monitor tumor growth in a rat glioma model. Visual limb placing, tactile limb placing, and beam walking tests were used to assess neurological deficits. Neurobehavioral alterations were correlated with PET findings and histopathological data. Seven days after surgery, the tumor was clearly visible on PET images. Results of behavioral tests correlated well with imaging data and histopathological findings. PET is feasible to detect experimental rat gliomas in their early stage of development. In contrast, standard neurological assessment is useful for monitoring tumor growth during the course of the disease.

Original languageEnglish
Pages (from-to)669-678
Number of pages10
JournalJournal of Neuro-Oncology
Volume104
Issue number3
DOIs
StatePublished - 09 2011

Keywords

  • Animal PET
  • Beam walking tests
  • Glioma tumor model
  • Tactile limb placing
  • Visual limb placing

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