Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa

W.-F. Chen; C.-T. Yin; Chih-Hsiu Cheng; M.-C. Lu; L.-S. Fang; W.-H. Wang; Z.-H. Wen; J.-J. Chen; Y.-C. Wu; P.-J. Sung

doi:10.3390/ijms16023298

Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa

W.-F. Chen
, C.-T. Yin
, Chih-Hsiu Cheng
, M.-C. Lu
, L.-S. Fang
, W.-H. Wang
, Z.-H. Wen
, J.-J. Chen
, Y.-C. Wu
, P.-J. Sung

School of Physical Therapy

Research output: Contribution to journal › Journal Article › peer-review

12 Scopus citations

Abstract

A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.

Original language	American English
Pages (from-to)	3298-3306
Journal	International Journal of Molecular Sciences
Volume	16
Issue number	2
DOIs	https://doi.org/10.3390/ijms16023298
State	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cembranoidal diterpene
Cytotoxicity
Sinularia numerosa
Sinuleptolide

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10.3390/ijms16023298

Cite this

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title = "Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa",

abstract = "A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.",

keywords = "Cembranoidal diterpene, Cytotoxicity, Sinularia numerosa, Sinuleptolide",

author = "W.-F. Chen and C.-T. Yin and Chih-Hsiu Cheng and M.-C. Lu and L.-S. Fang and W.-H. Wang and Z.-H. Wen and J.-J. Chen and Y.-C. Wu and P.-J. Sung",

year = "2015",

doi = "10.3390/ijms16023298",

language = "American English",

volume = "16",

pages = "3298--3306",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

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TY - JOUR

T1 - Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa

AU - Chen, W.-F.

AU - Yin, C.-T.

AU - Cheng, Chih-Hsiu

AU - Lu, M.-C.

AU - Fang, L.-S.

AU - Wang, W.-H.

AU - Wen, Z.-H.

AU - Chen, J.-J.

AU - Wu, Y.-C.

AU - Sung, P.-J.

PY - 2015

Y1 - 2015

N2 - A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.

AB - A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.

KW - Cembranoidal diterpene

KW - Cytotoxicity

KW - Sinularia numerosa

KW - Sinuleptolide

U2 - 10.3390/ijms16023298

DO - 10.3390/ijms16023298

M3 - Journal Article

C2 - 25654226

SN - 1661-6596

VL - 16

SP - 3298

EP - 3306

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 2

ER -

Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa

Abstract

UN SDGs

Keywords

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