Normal dopamine transporter binding in dopa responsive dystonia

Chin Chang Huang; Tzu Chen Yen; Yi Hsin Weng; Chin Song Lu

doi:10.1007/s00415-002-0776-3

Normal dopamine transporter binding in dopa responsive dystonia

Chin Chang Huang^*
, Tzu Chen Yen
, Yi Hsin Weng
, Chin Song Lu

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

42 Scopus citations

Abstract

We report the clinical manifestations of dopa responsive dystonia (DRD) in 2 patients from the same family. The brain magnetic resonance images (MRI) were normal. The dopamine transporter (DAT) imaging with ^99mTc-TRODAT-1 was performed in the 2 probands, 8 patients with young onset Parkinson disease (YOPD) and 16 normal controls. The ratios of ^99mTc-TRODAT-1 brain SPECT in the striatum were 2.40 ± 0.12 (right) and 2.30 ± 0.17 (left) in these 2 DRD patients as compared with 1.38 ± 0.18 (right), 1.41 ± 0.20 (left) in YOPD patients, and 2.15 ± 0.35 (right), 2.14 ± 0.32 (left) in normal controls respectively. A normal DAT uptake was found in DRD suggesting a normal presynaptic nigrostriatal dopaminergic terminal. We conclude that a normal DAT in parkinsonian patients can differentiate DRD from YOPD. In addition, DAT with ^99mTc-TRODAT-1 is a reliable and convenient tool to study the function of the presynaptic dopaminergic axonal terminals.

Original language	English
Pages (from-to)	1016-1020
Number of pages	5
Journal	Journal of Neurology
Volume	249
Issue number	8
DOIs	https://doi.org/10.1007/s00415-002-0776-3
State	Published - 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dopa responsive dystonia
Dopamine transporter
Parkinsonism
Segawa's disease
Tc-TRODAT-1

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10.1007/s00415-002-0776-3

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title = "Normal dopamine transporter binding in dopa responsive dystonia",

abstract = "We report the clinical manifestations of dopa responsive dystonia (DRD) in 2 patients from the same family. The brain magnetic resonance images (MRI) were normal. The dopamine transporter (DAT) imaging with 99mTc-TRODAT-1 was performed in the 2 probands, 8 patients with young onset Parkinson disease (YOPD) and 16 normal controls. The ratios of 99mTc-TRODAT-1 brain SPECT in the striatum were 2.40 ± 0.12 (right) and 2.30 ± 0.17 (left) in these 2 DRD patients as compared with 1.38 ± 0.18 (right), 1.41 ± 0.20 (left) in YOPD patients, and 2.15 ± 0.35 (right), 2.14 ± 0.32 (left) in normal controls respectively. A normal DAT uptake was found in DRD suggesting a normal presynaptic nigrostriatal dopaminergic terminal. We conclude that a normal DAT in parkinsonian patients can differentiate DRD from YOPD. In addition, DAT with 99mTc-TRODAT-1 is a reliable and convenient tool to study the function of the presynaptic dopaminergic axonal terminals.",

keywords = "Dopa responsive dystonia, Dopamine transporter, Parkinsonism, Segawa's disease, Tc-TRODAT-1",

author = "Huang, \{Chin Chang\} and Yen, \{Tzu Chen\} and Weng, \{Yi Hsin\} and Lu, \{Chin Song\}",

year = "2002",

doi = "10.1007/s00415-002-0776-3",

language = "英语",

volume = "249",

pages = "1016--1020",

journal = "Journal of Neurology",

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TY - JOUR

T1 - Normal dopamine transporter binding in dopa responsive dystonia

AU - Huang, Chin Chang

AU - Yen, Tzu Chen

AU - Weng, Yi Hsin

AU - Lu, Chin Song

PY - 2002

Y1 - 2002

N2 - We report the clinical manifestations of dopa responsive dystonia (DRD) in 2 patients from the same family. The brain magnetic resonance images (MRI) were normal. The dopamine transporter (DAT) imaging with 99mTc-TRODAT-1 was performed in the 2 probands, 8 patients with young onset Parkinson disease (YOPD) and 16 normal controls. The ratios of 99mTc-TRODAT-1 brain SPECT in the striatum were 2.40 ± 0.12 (right) and 2.30 ± 0.17 (left) in these 2 DRD patients as compared with 1.38 ± 0.18 (right), 1.41 ± 0.20 (left) in YOPD patients, and 2.15 ± 0.35 (right), 2.14 ± 0.32 (left) in normal controls respectively. A normal DAT uptake was found in DRD suggesting a normal presynaptic nigrostriatal dopaminergic terminal. We conclude that a normal DAT in parkinsonian patients can differentiate DRD from YOPD. In addition, DAT with 99mTc-TRODAT-1 is a reliable and convenient tool to study the function of the presynaptic dopaminergic axonal terminals.

AB - We report the clinical manifestations of dopa responsive dystonia (DRD) in 2 patients from the same family. The brain magnetic resonance images (MRI) were normal. The dopamine transporter (DAT) imaging with 99mTc-TRODAT-1 was performed in the 2 probands, 8 patients with young onset Parkinson disease (YOPD) and 16 normal controls. The ratios of 99mTc-TRODAT-1 brain SPECT in the striatum were 2.40 ± 0.12 (right) and 2.30 ± 0.17 (left) in these 2 DRD patients as compared with 1.38 ± 0.18 (right), 1.41 ± 0.20 (left) in YOPD patients, and 2.15 ± 0.35 (right), 2.14 ± 0.32 (left) in normal controls respectively. A normal DAT uptake was found in DRD suggesting a normal presynaptic nigrostriatal dopaminergic terminal. We conclude that a normal DAT in parkinsonian patients can differentiate DRD from YOPD. In addition, DAT with 99mTc-TRODAT-1 is a reliable and convenient tool to study the function of the presynaptic dopaminergic axonal terminals.

KW - Dopa responsive dystonia

KW - Dopamine transporter

KW - Parkinsonism

KW - Segawa's disease

KW - Tc-TRODAT-1

UR - https://www.scopus.com/pages/publications/0036039772

U2 - 10.1007/s00415-002-0776-3

DO - 10.1007/s00415-002-0776-3

M3 - 文章

C2 - 12195447

AN - SCOPUS:0036039772

SN - 0340-5354

VL - 249

SP - 1016

EP - 1020

JO - Journal of Neurology

JF - Journal of Neurology

IS - 8

ER -

Normal dopamine transporter binding in dopa responsive dystonia

Abstract

UN SDGs

Keywords

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