Novel open-ring analogues of N5,N10-methylenetetrahydrofolic acid with selective activity against brain tumor

Hui po Wang*, Tung shing Bai, On Lee, Kai der Ker

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

A series of 5-(4-substituted-1-piperazinyl)pyrimidines were synthesized as open-ring analogues of N5,N10-methylene-tetrahydrofolic acid. Compounds 6, 7, 8, 9 and 11 showed selective cytotoxicity on SNB75 human CNS cancer cell line with growth inhibition (GI50) ranged from 1.39 × 10-7 M to less than 10-8 M.

Original languageEnglish
Pages (from-to)1909-1912
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number17
DOIs
StatePublished - 07 09 1995
Externally publishedYes

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