Novel secoeunicellins produced by an octocoral Cladiella sp

Zhi Jun Zhang; Yi Hsuan Wang; Shu Rong Chen; Bo Rong Peng; San Nan Yang; Chiung Chih Hu; Lee Shing Fang; Tsong Long Hwang; Ping Jyun Sung

doi:10.1016/j.tetlet.2019.151300

Novel secoeunicellins produced by an octocoral Cladiella sp

Zhi Jun Zhang, Yi Hsuan Wang, Shu Rong Chen, Bo Rong Peng, San Nan Yang, Chiung Chih Hu, Lee Shing Fang, Tsong Long Hwang^*, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds.

Original language	English
Article number	151300
Journal	Tetrahedron Letters
Volume	60
Issue number	49
DOIs	https://doi.org/10.1016/j.tetlet.2019.151300
State	Published - 05 12 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

Anti-inflammatory
Cladiella
Octocoral
Secoeunicellin

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10.1016/j.tetlet.2019.151300

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@article{5a46e65ee22b40f98f4c53f483d97c5e,

title = "Novel secoeunicellins produced by an octocoral Cladiella sp",

abstract = "Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds.",

keywords = "Anti-inflammatory, Cladiella, Octocoral, Secoeunicellin",

author = "Zhang, {Zhi Jun} and Wang, {Yi Hsuan} and Chen, {Shu Rong} and Peng, {Bo Rong} and Yang, {San Nan} and Hu, {Chiung Chih} and Fang, {Lee Shing} and Hwang, {Tsong Long} and Sung, {Ping Jyun}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

day = "5",

doi = "10.1016/j.tetlet.2019.151300",

language = "英语",

volume = "60",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Novel secoeunicellins produced by an octocoral Cladiella sp

AU - Zhang, Zhi Jun

AU - Wang, Yi Hsuan

AU - Chen, Shu Rong

AU - Peng, Bo Rong

AU - Yang, San Nan

AU - Hu, Chiung Chih

AU - Fang, Lee Shing

AU - Hwang, Tsong Long

AU - Sung, Ping Jyun

PY - 2019/12/5

Y1 - 2019/12/5

N2 - Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds.

AB - Two novel 6,7-secoeunicellins, cladieunicellins W (1) and X (2), along with a known eunicellin, klymollin Y (3), were isolated from an octocoral identified as Cladiella sp. The structures of secoeunicellins 1 and 2 were elucidated by spectroscopic methods. 1 is the first secoeunicellin possessing a γ-lactone ring and 2 represents the first secoeunicellin possessing two tetrahydrofuran moieties. Secoeunicellin 2 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase. These results implied that the methoxy group at C-6 in 2 plays an important role in determining the activity of these compounds.

KW - Anti-inflammatory

KW - Cladiella

KW - Octocoral

KW - Secoeunicellin

UR - http://www.scopus.com/inward/record.url?scp=85074361360&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2019.151300

DO - 10.1016/j.tetlet.2019.151300

M3 - 文章

AN - SCOPUS:85074361360

SN - 0040-4039

VL - 60

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 49

M1 - 151300

ER -

Novel secoeunicellins produced by an octocoral Cladiella sp

Abstract

Bibliographical note

Keywords

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