NRIP enhances HPV gene expression via interaction with either GR or E2

Szu Wei Chang, Pei Yu Lu, Jih Huong Guo, Tzung Chieh Tsai, Yeou Ping Tsao, Show Li Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations


We previously identified a gene, nuclear receptor-interaction protein (NRIP), which functions as a transcription cofactor in glucocorticoid receptor (GR) and human papillomavirus E2 (HPV E2)-driven gene expression. Here, we comprehensively evaluated the role of NRIP in HPV-16 gene expression. NRIP acts as a transcription cofactor to enhance GR-regulated HPV-16 gene expression in the presence of hormone. NRIP also can form complex with E2 that caused NRIP-induced HPV gene expression via E2-binding sites in a hormone-independent manner. Furthermore, NRIP can associate with GR and E2 to form tri-protein complex to activate HPV gene expression via GRE, not the E2-binding site, in a hormone-dependent manner. These results indicate that NRIP and GR are viral E2-binding proteins and that NRIP regulates HPV gene expression via GRE and/or E2 binding site in the HPV promoter in a hormone-dependent or independent manner, respectively.

Original languageEnglish
Pages (from-to)38-48
Number of pages11
Issue number1
StatePublished - 05 02 2012
Externally publishedYes


  • E2
  • GR
  • HPV-16
  • Hormone
  • NRIP


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