O-glycosylation in liver cancer: Clinical associations and potential mechanisms

Kung Hao Liang, Chau Ting Yeh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Liver cancer can be an aggressive disease, and is highly prevalent in Asia and Africa. However, its currently approved therapeutic strategies are far from satisfactory. Recent progress in genomic, proteomic and glycomic profiling technologies have enabled the identification of biomarkers that significantly correlate with clinical outcomes. Many biomarkers are related to O-glycosylation of glycoproteins, which belong to an important but less-explored field of liver cancer biology. Here, we review these clinical studies and discuss potential underlying mechanisms.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalLiver Research
Volume1
Issue number4
DOIs
StatePublished - 12 2017

Bibliographical note

Publisher Copyright:
© 2017 The Third Affiliated Hospital of Sun Yat-sen University

Keywords

  • Biomarkers
  • Glycobiology
  • Glycosyltransferase
  • Hepatocellular carcinoma (HCC)
  • O-glycosylation
  • Post-translational modification

Fingerprint

Dive into the research topics of 'O-glycosylation in liver cancer: Clinical associations and potential mechanisms'. Together they form a unique fingerprint.

Cite this