Abstract
Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 285-293 |
| Number of pages | 9 |
| Journal | Chang Gung Medical Journal |
| Volume | 30 |
| Issue number | 4 |
| State | Published - 07 2007 |
Keywords
- Nucleolus
- Nucleophosmin/B23
- Tumorigenesis
