Abstract
Shear wave OCE (SW-OCE) is a novel technique that relies on the detection of the localized shear wave speed to map tissue elasticity. In this study, we demonstrate high speed imaging to capture single-shot transient shear wave propagation for SW-OCE. The fast imaging speed is achieved using a Fourier domain mode-locked (FDML) high-speed swept-source OCT (SS-OCT) system. The frame rate of shear wave imaging is 16 kHz, at an A-line rate of ∼1.62 MHz, enabling the detection of high-frequency shear waves up to 8 kHz in bandwidth. Several measures are taken to improve the phase-stability of the SS-OCT system, and the measured displacement sensitivity is ∼10 nanometers. To facilitate non-contact elastography, shear waves are generated with the photo-thermal effect using an ultra-violet pulsed laser. High frequency shear waves launched by the pulsed laser contain shorter wavelengths and carry rich localized elasticity information. Benefiting from single-shot acquisition, each SWI scan only takes 2.5 milliseconds, and the reconstruction of the elastogram can be performed in real-time with ∼20 Hz refresh rate. SW-OCE measurements are demonstrated on porcine cornea ex vivo. This study is the first demonstration of an all-optical method to perform real-time 3D SW-OCE. It is hoped that this technique will be applicable in the clinic to obtain high-resolution localized quantitative measurements of tissue biomechanical properties.
Original language | English |
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Title of host publication | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX |
Editors | Valery V. Tuchin, Joseph A. Izatt, James G. Fujimoto |
Publisher | SPIE |
ISBN (Electronic) | 9781628419313 |
DOIs | |
State | Published - 2016 |
Externally published | Yes |
Event | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX - San Francisco, United States Duration: 15 02 2016 → 17 02 2016 |
Publication series
Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
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Volume | 9697 |
ISSN (Print) | 1605-7422 |
Conference
Conference | Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX |
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Country/Territory | United States |
City | San Francisco |
Period | 15/02/16 → 17/02/16 |
Bibliographical note
Publisher Copyright:Copyright © 2016 SPIE.
Keywords
- Shear wave imaging
- elastography
- shear modulus