Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

Wen Ju Chen; Feng Yu Chang; Meng Tsan Tsai

doi:10.1117/12.2573215

Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

Wen Ju Chen
, Feng Yu Chang
, Meng Tsan Tsai^*

^*Corresponding author for this work

Department of Electrical Engineering

Chang Gung University
Chang Gung Memorial Hospital

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

Original language	English
Title of host publication	Biomedical Imaging and Sensing Conference 2020
Editors	Toyohiko Yatagai, Yoshihisa Aizu, Osamu Matoba, Yasuhiro Awatsuji, Yuan Luo
Publisher	SPIE
ISBN (Electronic)	9781510638495
DOIs	https://doi.org/10.1117/12.2573215
State	Published - 2020
Event	6th Biomedical Imaging and Sensing Conference - Yokohama, Japan Duration: 20 04 2020 → 24 04 2020

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11521
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	6th Biomedical Imaging and Sensing Conference
Country/Territory	Japan
City	Yokohama
Period	20/04/20 → 24/04/20

Bibliographical note

Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger

Keywords

Agriculture
Environment
Remote sensing
Robot arm
Robust control

Access to Document

10.1117/12.2573215

Cite this

Chen, W. J., Chang, F. Y., & Tsai, M. T. (2020). Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. In T. Yatagai, Y. Aizu, O. Matoba, Y. Awatsuji, & Y. Luo (Eds.), Biomedical Imaging and Sensing Conference 2020 Article 1152106 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11521). SPIE. https://doi.org/10.1117/12.2573215

Chen, Wen Ju ; Chang, Feng Yu ; Tsai, Meng Tsan. / Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. Biomedical Imaging and Sensing Conference 2020. editor / Toyohiko Yatagai ; Yoshihisa Aizu ; Osamu Matoba ; Yasuhiro Awatsuji ; Yuan Luo. SPIE, 2020. (Proceedings of SPIE - The International Society for Optical Engineering).

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title = "Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring",

abstract = "In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.",

keywords = "Agriculture, Environment, Remote sensing, Robot arm, Robust control",

author = "Chen, \{Wen Ju\} and Chang, \{Feng Yu\} and Tsai, \{Meng Tsan\}",

note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; 6th Biomedical Imaging and Sensing Conference ; Conference date: 20-04-2020 Through 24-04-2020",

year = "2020",

doi = "10.1117/12.2573215",

language = "英语",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

editor = "Toyohiko Yatagai and Yoshihisa Aizu and Osamu Matoba and Yasuhiro Awatsuji and Yuan Luo",

booktitle = "Biomedical Imaging and Sensing Conference 2020",

address = "美国",

}

Chen, WJ, Chang, FY & Tsai, MT 2020, Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. in T Yatagai, Y Aizu, O Matoba, Y Awatsuji & Y Luo (eds), Biomedical Imaging and Sensing Conference 2020., 1152106, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11521, SPIE, 6th Biomedical Imaging and Sensing Conference, Yokohama, Japan, 20/04/20. https://doi.org/10.1117/12.2573215

Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring. / Chen, Wen Ju; Chang, Feng Yu; Tsai, Meng Tsan.
Biomedical Imaging and Sensing Conference 2020. ed. / Toyohiko Yatagai; Yoshihisa Aizu; Osamu Matoba; Yasuhiro Awatsuji; Yuan Luo. SPIE, 2020. 1152106 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11521).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

AU - Chen, Wen Ju

AU - Chang, Feng Yu

AU - Tsai, Meng Tsan

N1 - Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

PY - 2020

Y1 - 2020

N2 - In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

AB - In this study, an integrated theranostic system combining a CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for tumor identification and treatment monitoring. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin and brain tumors on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

KW - Agriculture

KW - Environment

KW - Remote sensing

KW - Robot arm

KW - Robust control

UR - https://www.scopus.com/pages/publications/85087940303

U2 - 10.1117/12.2573215

DO - 10.1117/12.2573215

M3 - 会议稿件

AN - SCOPUS:85087940303

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Biomedical Imaging and Sensing Conference 2020

A2 - Yatagai, Toyohiko

A2 - Aizu, Yoshihisa

A2 - Matoba, Osamu

A2 - Awatsuji, Yasuhiro

A2 - Luo, Yuan

PB - SPIE

T2 - 6th Biomedical Imaging and Sensing Conference

Y2 - 20 April 2020 through 24 April 2020

ER -

Optical coherence tomography-guided laser therapy for tumor identification and treatment monitoring

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Keywords

Access to Document

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