Optical heterodyne surface plasmon resonance biosensor

Chien Chou*, Wen Chuan Kuo, Hsieh Ting Wu

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


A novel optical heterodyne surface plasmon resonance (SPR) biosensor using Zeeman laser is proposed. There are two surface plasma waves (SPWs) being excited by two correlated P polarized waves in an SPR device of Kretschmann configuration. The two reflected P waves are optically heterodyned so that the magnitude of the heterodyned signal is proportional to the multiplication of two attenuated reflected P waves. Then the detection sensitivity and the dynamical range based on this amplitude sensitive method are enhanced. In the experiment, the kinetics between mouse IgG and anti-mouse IgG is obtained according to the sensograms of different concentrations of anti-mouse IgG. The detection sensitivity corresponding to 0.2 nM is achieved. In addition, a concentration of 5 ng/ml of protein G interacting with mouse IgG is measured successfully.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2003
Externally publishedYes
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Fibers and Sensors for Medical Applications III - San Jose, CA, United States
Duration: 25 01 200328 01 2003


  • Biosensor
  • Optical heterodyne
  • Surface plasma wave (SPW)
  • Surface plasmon resonance (SPR)


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