Organocatalytic synthesis of temperature-sensitive degradable PNiPAAm-b-PTMC block copolymers and micellar characterizations

Ren Shen Lee; Wen Hsin Chen

doi:10.1016/j.reactfunctpolym.2011.01.005

Organocatalytic synthesis of temperature-sensitive degradable PNiPAAm-b-PTMC block copolymers and micellar characterizations

Ren Shen Lee^*, Wen Hsin Chen

^*Corresponding author for this work

Center for General Education

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

Amphiphilic PNiPAAm-b-PTMC were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by hydroxyl-terminated poly(N-isopropylacrylamide) (PNiPAAm) as the macroinitiator with the organocatalyst 1,5,7-triazabicyclo-[4.4.0]dec-5-ene (TBD). PNiPAAm-b-PTMC solutions had lower critical solution temperature (LCST) that depended on polymer composition and the solution media. The block copolymers form micelles in the aqueous phase with core-shell structure. Transmission electron microscopy analysis of micelle morphology revealed a spherical structure. Observations and determinations show high drug entrapment efficiency and drug-loading content for these drug micelles.

Original language	English
Pages (from-to)	455-462
Number of pages	8
Journal	Reactive and Functional Polymers
Volume	71
Issue number	4
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2011.01.005
State	Published - 04 2011

Keywords

Amphiphilic
Micelle
Organocatalyst
Poly(trimethylene carbonate)
Temperature-sensitive

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10.1016/j.reactfunctpolym.2011.01.005

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title = "Organocatalytic synthesis of temperature-sensitive degradable PNiPAAm-b-PTMC block copolymers and micellar characterizations",

abstract = "Amphiphilic PNiPAAm-b-PTMC were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by hydroxyl-terminated poly(N-isopropylacrylamide) (PNiPAAm) as the macroinitiator with the organocatalyst 1,5,7-triazabicyclo-[4.4.0]dec-5-ene (TBD). PNiPAAm-b-PTMC solutions had lower critical solution temperature (LCST) that depended on polymer composition and the solution media. The block copolymers form micelles in the aqueous phase with core-shell structure. Transmission electron microscopy analysis of micelle morphology revealed a spherical structure. Observations and determinations show high drug entrapment efficiency and drug-loading content for these drug micelles.",

keywords = "Amphiphilic, Micelle, Organocatalyst, Poly(trimethylene carbonate), Temperature-sensitive",

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T1 - Organocatalytic synthesis of temperature-sensitive degradable PNiPAAm-b-PTMC block copolymers and micellar characterizations

AU - Lee, Ren Shen

AU - Chen, Wen Hsin

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N2 - Amphiphilic PNiPAAm-b-PTMC were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by hydroxyl-terminated poly(N-isopropylacrylamide) (PNiPAAm) as the macroinitiator with the organocatalyst 1,5,7-triazabicyclo-[4.4.0]dec-5-ene (TBD). PNiPAAm-b-PTMC solutions had lower critical solution temperature (LCST) that depended on polymer composition and the solution media. The block copolymers form micelles in the aqueous phase with core-shell structure. Transmission electron microscopy analysis of micelle morphology revealed a spherical structure. Observations and determinations show high drug entrapment efficiency and drug-loading content for these drug micelles.

AB - Amphiphilic PNiPAAm-b-PTMC were synthesized by ring-opening polymerization of trimethylene carbonate (TMC) initiated by hydroxyl-terminated poly(N-isopropylacrylamide) (PNiPAAm) as the macroinitiator with the organocatalyst 1,5,7-triazabicyclo-[4.4.0]dec-5-ene (TBD). PNiPAAm-b-PTMC solutions had lower critical solution temperature (LCST) that depended on polymer composition and the solution media. The block copolymers form micelles in the aqueous phase with core-shell structure. Transmission electron microscopy analysis of micelle morphology revealed a spherical structure. Observations and determinations show high drug entrapment efficiency and drug-loading content for these drug micelles.

KW - Amphiphilic

KW - Micelle

KW - Organocatalyst

KW - Poly(trimethylene carbonate)

KW - Temperature-sensitive

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U2 - 10.1016/j.reactfunctpolym.2011.01.005

DO - 10.1016/j.reactfunctpolym.2011.01.005

M3 - 文章

AN - SCOPUS:79751536971

SN - 1381-5148

VL - 71

SP - 455

EP - 462

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

IS - 4

ER -

Organocatalytic synthesis of temperature-sensitive degradable PNiPAAm-b-PTMC block copolymers and micellar characterizations

Abstract

Keywords

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