Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group

Shih Hsiang Chen; Jiann Shiuh Chen; Shiann Tarng Jou; Kang Hsi Wu; Iou Jih Hung; Jiunn Ming Sheen; Meng Yao Lu; Bow Wen Chen; Tang Her Jaing; Shih Chung Wang; Ming Tsan Lin; Te Kau Chang; Hsi Che Liu; Chao Ping Yang

doi:10.1080/10428194.2018.1562182

Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group

Shih Hsiang Chen^*
, Jiann Shiuh Chen
, Shiann Tarng Jou
, Kang Hsi Wu
, Iou Jih Hung
, Jiunn Ming Sheen
, Meng Yao Lu
, Bow Wen Chen
, Tang Her Jaing
, Shih Chung Wang
, Ming Tsan Lin
, Te Kau Chang
, Hsi Che Liu
, Chao Ping Yang

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Studies of childhood anaplastic large cell lymphoma (ALCL) are less reported from East Asian countries. Clinical features and outcome of 90 children with ALCL in Taiwan were analyzed. The median age at diagnosis was 11.7 years. The most common presentation was lymph node involvement (86.7%). Advanced diseases accounted for 70% of patients at diagnosis. Most patients (93.1%) had positive staining for anaplastic lymphoma kinase. The five-year overall survival and event-free survival (EFS) rates were 79.7% and 73.3%, respectively. Bone marrow involvement, advanced stage, and thoracopulmonary ALCL were adverse prognostic factors for EFS (p=.05,.04, and.03, respectively). In multivariate analysis, only thoracopulmonary ALCL had a marginal significance on worse EFS (p= .054). We suggested that children with thoracopulmonary ALCL may need to intensify the treatment, and introduction of new targeted therapies for relapsed/refractory disease will be required.

Original language	English
Pages (from-to)	1942-1949
Number of pages	8
Journal	Leukemia and Lymphoma
Volume	60
Issue number	8
DOIs	https://doi.org/10.1080/10428194.2018.1562182
State	Published - 03 07 2019

Bibliographical note

Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anaplastic large cell lymphoma
Taiwan Pediatric Oncology Group
children
outcome

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10.1080/10428194.2018.1562182

Cite this

Chen, S. H., Chen, J. S., Jou, S. T., Wu, K. H., Hung, I. J., Sheen, J. M., Lu, M. Y., Chen, B. W., Jaing, T. H., Wang, S. C., Lin, M. T., Chang, T. K., Liu, H. C., & Yang, C. P. (2019). Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group. Leukemia and Lymphoma, 60(8), 1942-1949. https://doi.org/10.1080/10428194.2018.1562182

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title = "Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group",

abstract = "Studies of childhood anaplastic large cell lymphoma (ALCL) are less reported from East Asian countries. Clinical features and outcome of 90 children with ALCL in Taiwan were analyzed. The median age at diagnosis was 11.7 years. The most common presentation was lymph node involvement (86.7\%). Advanced diseases accounted for 70\% of patients at diagnosis. Most patients (93.1\%) had positive staining for anaplastic lymphoma kinase. The five-year overall survival and event-free survival (EFS) rates were 79.7\% and 73.3\%, respectively. Bone marrow involvement, advanced stage, and thoracopulmonary ALCL were adverse prognostic factors for EFS (p=.05,.04, and.03, respectively). In multivariate analysis, only thoracopulmonary ALCL had a marginal significance on worse EFS (p= .054). We suggested that children with thoracopulmonary ALCL may need to intensify the treatment, and introduction of new targeted therapies for relapsed/refractory disease will be required.",

keywords = "Anaplastic large cell lymphoma, Taiwan Pediatric Oncology Group, children, outcome",

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note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor \& Francis Group.",

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doi = "10.1080/10428194.2018.1562182",

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AU - Jou, Shiann Tarng

AU - Wu, Kang Hsi

AU - Hung, Iou Jih

AU - Sheen, Jiunn Ming

AU - Lu, Meng Yao

AU - Chen, Bow Wen

AU - Jaing, Tang Her

AU - Wang, Shih Chung

AU - Lin, Ming Tsan

AU - Chang, Te Kau

AU - Liu, Hsi Che

AU - Yang, Chao Ping

PY - 2019/7/3

Y1 - 2019/7/3

N2 - Studies of childhood anaplastic large cell lymphoma (ALCL) are less reported from East Asian countries. Clinical features and outcome of 90 children with ALCL in Taiwan were analyzed. The median age at diagnosis was 11.7 years. The most common presentation was lymph node involvement (86.7%). Advanced diseases accounted for 70% of patients at diagnosis. Most patients (93.1%) had positive staining for anaplastic lymphoma kinase. The five-year overall survival and event-free survival (EFS) rates were 79.7% and 73.3%, respectively. Bone marrow involvement, advanced stage, and thoracopulmonary ALCL were adverse prognostic factors for EFS (p=.05,.04, and.03, respectively). In multivariate analysis, only thoracopulmonary ALCL had a marginal significance on worse EFS (p= .054). We suggested that children with thoracopulmonary ALCL may need to intensify the treatment, and introduction of new targeted therapies for relapsed/refractory disease will be required.

AB - Studies of childhood anaplastic large cell lymphoma (ALCL) are less reported from East Asian countries. Clinical features and outcome of 90 children with ALCL in Taiwan were analyzed. The median age at diagnosis was 11.7 years. The most common presentation was lymph node involvement (86.7%). Advanced diseases accounted for 70% of patients at diagnosis. Most patients (93.1%) had positive staining for anaplastic lymphoma kinase. The five-year overall survival and event-free survival (EFS) rates were 79.7% and 73.3%, respectively. Bone marrow involvement, advanced stage, and thoracopulmonary ALCL were adverse prognostic factors for EFS (p=.05,.04, and.03, respectively). In multivariate analysis, only thoracopulmonary ALCL had a marginal significance on worse EFS (p= .054). We suggested that children with thoracopulmonary ALCL may need to intensify the treatment, and introduction of new targeted therapies for relapsed/refractory disease will be required.

KW - Anaplastic large cell lymphoma

KW - Taiwan Pediatric Oncology Group

KW - children

KW - outcome

UR - https://www.scopus.com/pages/publications/85060179179

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DO - 10.1080/10428194.2018.1562182

M3 - 文章

C2 - 30646784

AN - SCOPUS:85060179179

SN - 1042-8194

VL - 60

SP - 1942

EP - 1949

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 8

ER -

Outcome and prognosis of anaplastic large cell lymphoma in children: a report from the Taiwan Pediatric Oncology Group

Abstract

Bibliographical note

UN SDGs

Keywords

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