Outcomes of acute aortic dissection surgery in octogenarians

Ming En Hsu, An Hsun Chou, Yu Ting Cheng, Hsiu An Lee, Kuo Sheng Liu, Dong Yi Chen, Victor Chien Chia Wu, Pao Hsien Chu, Tien Hsing Chen, Shao Wei Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

17 Scopus citations

Abstract

BACKGROUND: Octogenarians (≥80 years old) are high-risk patients for acute aortic dissection (AAD) surgery. However, no population-based study has investigated the late outcomes of AAD surgery in octogenarians. This study aimed to investigate the late outcomes of AAD surgery in octogenarians. METHODS AND RESULTS: A total of 3998 patients who received AAD surgery from 2005 to 2013 were identified from the Taiwan National Health Insurance Research Database. In-hospital complications and late outcomes including all-cause mortality, major adverse cardiac and cerebrovascular event, respiratory failure, and redo aortic surgery were evaluated. The risks of late outcomes between octogenarians and nonoctogenarians were compared using the multivariable Cox proportional hazard model or Fine and Gray competing model. The numbers of the octogenarians who underwent type A and B AAD surgeries were 206 (6%; 206/3423) and 79 (13.7%; 79/575), respectively. Compared with the nonoctogenarians, the type A octogenarians had higher risks of in-hospital mortality and several in-hospital complications, whereas the type B octogenarians did not. Furthermore, compared with the nonoctogenarians, the type A octogenarians had a higher risk of all-cause mortality (61.7% vs 32.5%; hazard ratio [HR], 2.35; 95% CI, 1.95–2.84) and a higher cumulative incidence of major adverse cardiac and cerebrovascular event and respiratory failure, and the type B octogenarians demonstrated a higher risk of all-cause mortality (44.3% vs 30.4%; HR, 1.74; 95% CI, 1.18–2.55). The octogenarians receiving AAD surgeries had higher mortality rates than the normal octogenarian population. CONCLUSIONS: Octogenarians receiving AAD surgeries exhibit worse late outcomes than nonoctogenarian counterparts.

Original languageEnglish
Article numbere017147
JournalJournal of the American Heart Association
Volume9
Issue number18
DOIs
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors.

Keywords

  • Acute aortic dissection
  • Age
  • Aortic dissection
  • Aortic dissection surgery
  • Octogenarian

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