Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation

Chih Chi Wang; Salvador Lopez-Valdes; Ting Lung Lin; Anthony Yap; Chee Chien Yong; Wei Feng Li; Shih Ho Wang; Chih Che Lin; Yueh Wei Liu; Tsan Shiun Lin; Allan M. Concejero; Hock Liew Eng; Douglas Henry; Yu Fan Cheng; Bruno Jawan; Chao Long Chen

doi:10.1002/lt.23785

Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation

Chih Chi Wang^*, Salvador Lopez-Valdes, Ting Lung Lin, Anthony Yap, Chee Chien Yong, Wei Feng Li, Shih Ho Wang, Chih Che Lin, Yueh Wei Liu, Tsan Shiun Lin, Allan M. Concejero, Hock Liew Eng, Douglas Henry, Yu Fan Cheng, Bruno Jawan, Chao Long Chen

^*Corresponding author for this work

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

12 Scopus citations

Abstract

The outflow reconstruction of the right anterior sector in a right liver graft (RLG) with cryopreserved vascular grafts (CVGs) is crucial for preventing graft congestion in living donor liver transplantation (LDLT). The impact of the duration of cryopreservation has not been evaluated so far. From 2006 to 2009, 250 LDLT were performed: 47 of these patients (group 1) received CVGs stored for â‰1 year, and 33 patients (group 2) received CVGs stored for >1 year. Single or multiple segment 8 hepatic veins were reconstructed. The number of anastomoses did not affect vascular graft patency (P = 0.21). The length of the cryopreservation time did not affect the histological findings for CVGs. The preoperative and postoperative liver graft volumes were 783.8 ± 129.7 and 1102 ± 194.7 cc, respectively, for group 1 and 753.7 ± 158.5 and 1097.2 ± 178.7 cc, respectively, for group 2. The regeneration indices for liver grafts in the whole patient group, group 1, and group 2 were 48.9%, 47.4%, and 51.05%, respectively. In conclusion, the storage duration has no impact on the patency of CVGs in outflow reconstruction or on the regeneration of RLGs in LDLT. CVGs stored for >1 year can be safely used for the outflow reconstruction of RLGs in LDLT.

Original language	English
Pages (from-to)	173-181
Number of pages	9
Journal	Liver Transplantation
Volume	20
Issue number	2
DOIs	https://doi.org/10.1002/lt.23785
State	Published - 02 2014

Access to Document

10.1002/lt.23785

Cite this

Wang, C. C., Lopez-Valdes, S., Lin, T. L., Yap, A., Yong, C. C., Li, W. F., Wang, S. H., Lin, C. C., Liu, Y. W., Lin, T. S., Concejero, A. M., Eng, H. L., Henry, D., Cheng, Y. F., Jawan, B., & Chen, C. L. (2014). Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation. Liver Transplantation, 20(2), 173-181. https://doi.org/10.1002/lt.23785

@article{e918c6846e0b4d6eb0154a33effe6d33,

title = "Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation",

abstract = "The outflow reconstruction of the right anterior sector in a right liver graft (RLG) with cryopreserved vascular grafts (CVGs) is crucial for preventing graft congestion in living donor liver transplantation (LDLT). The impact of the duration of cryopreservation has not been evaluated so far. From 2006 to 2009, 250 LDLT were performed: 47 of these patients (group 1) received CVGs stored for {\^a}‰1 year, and 33 patients (group 2) received CVGs stored for >1 year. Single or multiple segment 8 hepatic veins were reconstructed. The number of anastomoses did not affect vascular graft patency (P = 0.21). The length of the cryopreservation time did not affect the histological findings for CVGs. The preoperative and postoperative liver graft volumes were 783.8 ± 129.7 and 1102 ± 194.7 cc, respectively, for group 1 and 753.7 ± 158.5 and 1097.2 ± 178.7 cc, respectively, for group 2. The regeneration indices for liver grafts in the whole patient group, group 1, and group 2 were 48.9%, 47.4%, and 51.05%, respectively. In conclusion, the storage duration has no impact on the patency of CVGs in outflow reconstruction or on the regeneration of RLGs in LDLT. CVGs stored for >1 year can be safely used for the outflow reconstruction of RLGs in LDLT.",

author = "Wang, {Chih Chi} and Salvador Lopez-Valdes and Lin, {Ting Lung} and Anthony Yap and Yong, {Chee Chien} and Li, {Wei Feng} and Wang, {Shih Ho} and Lin, {Chih Che} and Liu, {Yueh Wei} and Lin, {Tsan Shiun} and Concejero, {Allan M.} and Eng, {Hock Liew} and Douglas Henry and Cheng, {Yu Fan} and Bruno Jawan and Chen, {Chao Long}",

year = "2014",

month = feb,

doi = "10.1002/lt.23785",

language = "英语",

volume = "20",

pages = "173--181",

journal = "Liver Transplantation",

issn = "1527-6465",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

Wang, CC, Lopez-Valdes, S, Lin, TL, Yap, A, Yong, CC, Li, WF, Wang, SH, Lin, CC, Liu, YW, Lin, TS, Concejero, AM, Eng, HL, Henry, D, Cheng, YF, Jawan, B & Chen, CL 2014, 'Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation', Liver Transplantation, vol. 20, no. 2, pp. 173-181. https://doi.org/10.1002/lt.23785

TY - JOUR

T1 - Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation

AU - Wang, Chih Chi

AU - Lopez-Valdes, Salvador

AU - Lin, Ting Lung

AU - Yap, Anthony

AU - Yong, Chee Chien

AU - Li, Wei Feng

AU - Wang, Shih Ho

AU - Lin, Chih Che

AU - Liu, Yueh Wei

AU - Lin, Tsan Shiun

AU - Concejero, Allan M.

AU - Eng, Hock Liew

AU - Henry, Douglas

AU - Cheng, Yu Fan

AU - Jawan, Bruno

AU - Chen, Chao Long

PY - 2014/2

Y1 - 2014/2

N2 - The outflow reconstruction of the right anterior sector in a right liver graft (RLG) with cryopreserved vascular grafts (CVGs) is crucial for preventing graft congestion in living donor liver transplantation (LDLT). The impact of the duration of cryopreservation has not been evaluated so far. From 2006 to 2009, 250 LDLT were performed: 47 of these patients (group 1) received CVGs stored for â‰1 year, and 33 patients (group 2) received CVGs stored for >1 year. Single or multiple segment 8 hepatic veins were reconstructed. The number of anastomoses did not affect vascular graft patency (P = 0.21). The length of the cryopreservation time did not affect the histological findings for CVGs. The preoperative and postoperative liver graft volumes were 783.8 ± 129.7 and 1102 ± 194.7 cc, respectively, for group 1 and 753.7 ± 158.5 and 1097.2 ± 178.7 cc, respectively, for group 2. The regeneration indices for liver grafts in the whole patient group, group 1, and group 2 were 48.9%, 47.4%, and 51.05%, respectively. In conclusion, the storage duration has no impact on the patency of CVGs in outflow reconstruction or on the regeneration of RLGs in LDLT. CVGs stored for >1 year can be safely used for the outflow reconstruction of RLGs in LDLT.

AB - The outflow reconstruction of the right anterior sector in a right liver graft (RLG) with cryopreserved vascular grafts (CVGs) is crucial for preventing graft congestion in living donor liver transplantation (LDLT). The impact of the duration of cryopreservation has not been evaluated so far. From 2006 to 2009, 250 LDLT were performed: 47 of these patients (group 1) received CVGs stored for â‰1 year, and 33 patients (group 2) received CVGs stored for >1 year. Single or multiple segment 8 hepatic veins were reconstructed. The number of anastomoses did not affect vascular graft patency (P = 0.21). The length of the cryopreservation time did not affect the histological findings for CVGs. The preoperative and postoperative liver graft volumes were 783.8 ± 129.7 and 1102 ± 194.7 cc, respectively, for group 1 and 753.7 ± 158.5 and 1097.2 ± 178.7 cc, respectively, for group 2. The regeneration indices for liver grafts in the whole patient group, group 1, and group 2 were 48.9%, 47.4%, and 51.05%, respectively. In conclusion, the storage duration has no impact on the patency of CVGs in outflow reconstruction or on the regeneration of RLGs in LDLT. CVGs stored for >1 year can be safely used for the outflow reconstruction of RLGs in LDLT.

UR - http://www.scopus.com/inward/record.url?scp=84894942596&partnerID=8YFLogxK

U2 - 10.1002/lt.23785

DO - 10.1002/lt.23785

M3 - 文章

C2 - 24382821

AN - SCOPUS:84894942596

SN - 1527-6465

VL - 20

SP - 173

EP - 181

JO - Liver Transplantation

JF - Liver Transplantation

IS - 2

ER -

Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this