TY - JOUR
T1 - Ovarian Response to Gonadotropins in Patients With Tubal Factor Infertility
T2 - Salpingectomy Versus Nonsalpingectomy
AU - Lin, Yu Ju
AU - Ou, Yu Che
AU - Huang, Fu Jen
AU - Lin, Pin Yao
AU - Kung, Fu Tsai
AU - Lan, Kuo Chung
PY - 2013/9
Y1 - 2013/9
N2 - Study Objective: To evaluate the effects of salpingectomy on the ovarian response to gonadotropins and invitro fertilization-embryo transfer (IVF-ET) cycle outcomes in women with tubal factor infertility. Design: A retrospective study (Canadian Task Force Classification II-3). Setting: An invitro fertilization laboratory in a university hospital in Taiwan. Patients: We analyzed the outcomes of 288 consecutive fresh IVF-ET cycles in 251 consecutive women with tubal factor infertility from January 2001 to December 2011. Two hundred eighty-eight cycles were divided into 2 groups comprising 103 cycles with laparoscopic salpingectomy and 185 cycles with prior bilateral tubal sterilization, laparoscopic tuboplasty, or proximal tubal occlusion as the control group. Interventions: Controlled ovarian hyperstimulation and IVF-ET. Measurements and Main Results: The main outcome was measured by comparing the duration of stimulation, number of gonadotropin ampoules per cycle, number of follicles, number of oocytes retrieved, fertilization rate, implantation rate, clinical pregnancy rate, and live birth rate. We observed no significant difference in any ovarian response parameter between the salpingectomy and nonsalpingectomy groups. Implantation rates, clinical pregnancy rates, and live birth rates were similar. The mean numbers of follicles and oocytes retrieved ipsilateral to the operated side in the salpingectomy group were similar to the numbers of follicles and oocytes retrieved from the nonoperated ovary. Conclusions: Laparoscopic salpingectomy did not have a negative effect on the ovarian response in women with tubal factor infertility.
AB - Study Objective: To evaluate the effects of salpingectomy on the ovarian response to gonadotropins and invitro fertilization-embryo transfer (IVF-ET) cycle outcomes in women with tubal factor infertility. Design: A retrospective study (Canadian Task Force Classification II-3). Setting: An invitro fertilization laboratory in a university hospital in Taiwan. Patients: We analyzed the outcomes of 288 consecutive fresh IVF-ET cycles in 251 consecutive women with tubal factor infertility from January 2001 to December 2011. Two hundred eighty-eight cycles were divided into 2 groups comprising 103 cycles with laparoscopic salpingectomy and 185 cycles with prior bilateral tubal sterilization, laparoscopic tuboplasty, or proximal tubal occlusion as the control group. Interventions: Controlled ovarian hyperstimulation and IVF-ET. Measurements and Main Results: The main outcome was measured by comparing the duration of stimulation, number of gonadotropin ampoules per cycle, number of follicles, number of oocytes retrieved, fertilization rate, implantation rate, clinical pregnancy rate, and live birth rate. We observed no significant difference in any ovarian response parameter between the salpingectomy and nonsalpingectomy groups. Implantation rates, clinical pregnancy rates, and live birth rates were similar. The mean numbers of follicles and oocytes retrieved ipsilateral to the operated side in the salpingectomy group were similar to the numbers of follicles and oocytes retrieved from the nonoperated ovary. Conclusions: Laparoscopic salpingectomy did not have a negative effect on the ovarian response in women with tubal factor infertility.
KW - Controlled ovarian hyperstimulation
KW - Invitro fertilization
KW - Ovarian response
KW - Salpingectomy
UR - http://www.scopus.com/inward/record.url?scp=84883748018&partnerID=8YFLogxK
U2 - 10.1016/j.jmig.2013.04.005
DO - 10.1016/j.jmig.2013.04.005
M3 - 文章
C2 - 23706676
AN - SCOPUS:84883748018
SN - 1553-4650
VL - 20
SP - 637
EP - 641
JO - Journal of Minimally Invasive Gynecology
JF - Journal of Minimally Invasive Gynecology
IS - 5
ER -