Ovatodiolide inhibits the maturation of allergen-induced bone marrow-derived dendritic cells and induction of Th2 cell differentiation

Yerra Koteswara Rao, Yu Ching Chen, Shih Hua Fang, Chih Ho Lai, Madamanchi Geethangili, Chen Chen Lee*, Yew Min Tzeng

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

15 Scopus citations

Abstract

Ovatodiolide was a unique macrocyclic diterpenoid isolated from the traditional Chinese medicinal herb Anisomeles indica. The present study attempted to examine the ovatodiolide effects on dendritic cell (DC) maturation and immuno-stimulatory activities. The effects of ovatodiolide on DC surface molecule expression, cytokine production, and capacity to induce T-cell differentiation were examined in ovalbumin (OVA)/thymic stromal lymphopoietin (TSLP)-stimulated DCs. Ovatodiolide attenuated the expression of DC surface molecules CD80, CD86, histocompatibility complex (MHC) class II, and Th2 subset of CD4+ T cells co-stimulatory molecule-OX40 ligand production. Additionally, ovatodiolide suppressed the CD4+ T cells proliferation, and production of inflammatory cytokines interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-α. This study may be useful to develop ovatodiolide as a therapeutic adjuvant.

Original languageEnglish
Pages (from-to)617-624
Number of pages8
JournalInternational Immunopharmacology
Volume17
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • CD80
  • CD86
  • Dendritic cell maturation
  • Inflammatory cytokines
  • MHC class II
  • Ovatodiolide

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