Overexpression and elevated plasma level of tumor-associated antigen 90K/Mac-2 binding protein in colorectal carcinoma

Chih Ching Wu, Yu Shan Huang, Li Yu Lee, Ying Liang, Rei Ping Tang, Yu Sun Chang, Ling Ling Hsieh, Jau Song Yu

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations


The cancer cell secretome may contain potentially useful biomarkers. Previously, we have analyzed the colorectal carcinoma (CRC) cell secretome. In this study, tumor-associated antigen 90K (TAA90K)/Mac-2 binding protein (Mac-2BP), one of the CRC cell secreted proteins, was chosen for evaluation as a potential CRC biomarker because its mRNA level was also found to be significantly elevated in CRC tissues and in a more metastatic CRC cell line from the analysis of two public domain array-based datasets. Immunohistochemical analysis of 241 CRC specimens showed that TAA90K/Mac-2BP was positively detected in 52.7% of the tumors, but weakly or not detected in over 95% of the adjacent nontumor epithelial cells. The plasma TAA90K/Mac-2BP levels were significantly higher in CRC patients (N = 280) versus healthy controls (N = 147) (7.77 ± 3.49 vs. 5.72 ± 2.67 μg/mL, p<0.001). Moreover, combination of TAA90K/Mac-2BP and carcinoembryonic antigen (CEA) could outperform CEA alone in discriminating CRC patients from healthy persons in this case-control study. Our results collectively indicate that analysis of cancer cell secretome is a feasible strategy for identifying cancer biomarker candidates, and the TAA90K/Mac-2BP may be a potential CRC biomarker.

Original languageEnglish
Pages (from-to)1586-1595
Number of pages10
JournalProteomics - Clinical Applications
Issue number12
StatePublished - 2008


  • Biomarker
  • Colorectal carcinoma
  • Mac-2BP
  • Secretome
  • TAA90K


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