Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities

Li Ting Cheng, Sheng Qi Luo, Bor Cherng Hong*, Chia Ling Chen, Wen Shan Li*, Gene Hsiang Lee

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations

Abstract

Incorporation of water has been revealed to successfully facilitate visible-light photoredox catalysis of indole leading to increased production of C2-quaternary indolinone. The water-promoted photoreaction of indole under catalyst-free conditions by a household compact fluorescence light was also demonstrated. The antiproliferative activity of the synthesized indolinones was evaluated against three human cancer cell lines.

Original languageEnglish
Pages (from-to)6247-6252
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume18
Issue number32
DOIs
StatePublished - 28 08 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Royal Society of Chemistry.

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