Oxygen, arterial blood gases and ventilation are unchanged during dialysis in patients receiving pressure support ventilation

C. C. Huang*, M. C. Lin, C. T. Yang, R. S. Lan, Y. H. Tsai, T. C.Y. Tsao

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

7 Scopus citations

Abstract

This study was undertaken to observe whether dialysis-induced alveolar hypoventilation and arterial hypoxaemia occur during bicarbonate haemodialysis in patients receiving partial mechanical support with pressure support ventilation. Nineteen patients admitted to the medical intensive care unit requiring mechanical ventilation and haemodialysis were enrolled. Arterial blood gas, white blood cell (WBC) count, minute ventilation, respiratory rate, breathing pattern and blood pressure were measured according to the following time schedule: pre-dialysis (time 0), and at 15, 30, 60, 120, 180, 240 min thereafter. Results showed that, with the use of cuprammonium dialyser, the WBC count dropped immediately and reached the nadir 15 min after haemodialysis. Thereafter, it recovered and overshot the pre-dialysis values until the end of dialysis. The bicarbonate dialysate indeed resulted in rapid and significant metabolic alkalosis. However, no decrease of PaO2 occurred throughout haemodialysis. The tidal volume, minute ventilation and breathing pattern remained stable during haemodialysis. We conclude that neither dialysis-induced alveolar hypoventilation nor arterial hypoxaemia developed during bicarbonate dialysis in patients mechanically ventilated with the pressure support ventilation.

Original languageEnglish
Pages (from-to)534-540
Number of pages7
JournalRespiratory Medicine
Volume92
Issue number3
DOIs
StatePublished - 03 1998

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