p53 gene mutations in brain tumors in Taiwan

Ling Ling Hsieh; Chang Feng Hsia; Li Yu Wang; Chien Jen Chen; Yat Sen Ho

doi:10.1016/0304-3835(94)90027-2

p53 gene mutations in brain tumors in Taiwan

Ling Ling Hsieh^*, Chang Feng Hsia, Li Yu Wang, Chien Jen Chen, Yat Sen Ho

^*Corresponding author for this work

Department of Public Health

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Mutations of the p53 gene were investigated in 116 surgically removed primary brain tumor tissues by PCR-SSCP analysis. The mutations did not follow a random distribution among the various different subtypes, but occurred in 21.0% ( 13 62) of astrocytomas, 13.0% ( 3 23) of oligodendrogliomas and 35% ( 7 20) of PNETs. No mutation was found in the ependymomas. The majority of mutations identified in this study were G:C to A:T or C:G to T:A transitions (56.0%, 14 of 25) and occurred most frequently (56.0%, 14 of 25) at sites of CpG dinucleotides. Interestingly, codon 158 is a new hot spot which occurred with a frequency of 16.0% (4 of 25) in the samples analyzed.

Original language	English
Pages (from-to)	25-32
Number of pages	8
Journal	Cancer Letters
Volume	78
Issue number	1-3
DOIs	https://doi.org/10.1016/0304-3835(94)90027-2
State	Published - 01 04 1994

Keywords

Brain tumor
PCR-SSCP
p53 gene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(94)90027-2

Cite this

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title = "p53 gene mutations in brain tumors in Taiwan",

abstract = "Mutations of the p53 gene were investigated in 116 surgically removed primary brain tumor tissues by PCR-SSCP analysis. The mutations did not follow a random distribution among the various different subtypes, but occurred in 21.0% ( 13 62) of astrocytomas, 13.0% ( 3 23) of oligodendrogliomas and 35% ( 7 20) of PNETs. No mutation was found in the ependymomas. The majority of mutations identified in this study were G:C to A:T or C:G to T:A transitions (56.0%, 14 of 25) and occurred most frequently (56.0%, 14 of 25) at sites of CpG dinucleotides. Interestingly, codon 158 is a new hot spot which occurred with a frequency of 16.0% (4 of 25) in the samples analyzed.",

keywords = "Brain tumor, PCR-SSCP, p53 gene",

author = "Hsieh, {Ling Ling} and Hsia, {Chang Feng} and Wang, {Li Yu} and Chen, {Chien Jen} and Ho, {Yat Sen}",

year = "1994",

month = apr,

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doi = "10.1016/0304-3835(94)90027-2",

language = "英语",

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journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

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TY - JOUR

T1 - p53 gene mutations in brain tumors in Taiwan

AU - Hsieh, Ling Ling

AU - Hsia, Chang Feng

AU - Wang, Li Yu

AU - Chen, Chien Jen

AU - Ho, Yat Sen

PY - 1994/4/1

Y1 - 1994/4/1

N2 - Mutations of the p53 gene were investigated in 116 surgically removed primary brain tumor tissues by PCR-SSCP analysis. The mutations did not follow a random distribution among the various different subtypes, but occurred in 21.0% ( 13 62) of astrocytomas, 13.0% ( 3 23) of oligodendrogliomas and 35% ( 7 20) of PNETs. No mutation was found in the ependymomas. The majority of mutations identified in this study were G:C to A:T or C:G to T:A transitions (56.0%, 14 of 25) and occurred most frequently (56.0%, 14 of 25) at sites of CpG dinucleotides. Interestingly, codon 158 is a new hot spot which occurred with a frequency of 16.0% (4 of 25) in the samples analyzed.

AB - Mutations of the p53 gene were investigated in 116 surgically removed primary brain tumor tissues by PCR-SSCP analysis. The mutations did not follow a random distribution among the various different subtypes, but occurred in 21.0% ( 13 62) of astrocytomas, 13.0% ( 3 23) of oligodendrogliomas and 35% ( 7 20) of PNETs. No mutation was found in the ependymomas. The majority of mutations identified in this study were G:C to A:T or C:G to T:A transitions (56.0%, 14 of 25) and occurred most frequently (56.0%, 14 of 25) at sites of CpG dinucleotides. Interestingly, codon 158 is a new hot spot which occurred with a frequency of 16.0% (4 of 25) in the samples analyzed.

KW - Brain tumor

KW - PCR-SSCP

KW - p53 gene

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U2 - 10.1016/0304-3835(94)90027-2

DO - 10.1016/0304-3835(94)90027-2

M3 - 文章

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AN - SCOPUS:0028334844

SN - 0304-3835

VL - 78

SP - 25

EP - 32

JO - Cancer Letters

JF - Cancer Letters

IS - 1-3

ER -

p53 gene mutations in brain tumors in Taiwan

Abstract

Keywords

UN SDGs

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