TY - JOUR
T1 - Parental decisions regarding prenatally detected fetal sex chromosomal abnormality and the impact of genetic counselling
T2 - An analysis of 57 cases in Taiwan
AU - Shaw, Sheng Wen
AU - Chueh, Ho Yen
AU - Chang, Shuenn Dyh
AU - Cheng, Po Jen
AU - Hsieh, T'sang T.ang
AU - Soong, Yung Kuei
PY - 2008/4
Y1 - 2008/4
N2 - Objective: To analyse parental decisions regarding pregnancies with sex chromosome abnormalities (SCA). Methods: Collected and reviewed records from our hospital for 1991-2005. Genetic counselling was provided by obstetricians or perinatologists. Result: Among 57 fetuses with SCA were 36 non-mosaic cases (four of 36, 45,X; 12 of 36, 47,XXY; seven of 36, 47,XYY, 13 of 36, 47,XXX) and 21 mosaic cases (15 of 21, 45,X mosaicism). Only 20% of 45,X mosaic pregnancies were continued, whereas all other mosaic pregnancies (100%) were continued (P = 0.004). Of 32 SCA cases counselled by a perinatologist, 66% (21 of 32) were continued. In contrast, 36% (nine of 25) of cases counselled by a general obstetrician were continued, a barely significant difference (P = 0.048). More couples chose to continue pregnancies in recent years. Conclusion: Genetic counselling by well-trained specialists is valuable, and the trend towards fewer terminations at our centre suggests improved parental knowledge of pathology associated with SCA.
AB - Objective: To analyse parental decisions regarding pregnancies with sex chromosome abnormalities (SCA). Methods: Collected and reviewed records from our hospital for 1991-2005. Genetic counselling was provided by obstetricians or perinatologists. Result: Among 57 fetuses with SCA were 36 non-mosaic cases (four of 36, 45,X; 12 of 36, 47,XXY; seven of 36, 47,XYY, 13 of 36, 47,XXX) and 21 mosaic cases (15 of 21, 45,X mosaicism). Only 20% of 45,X mosaic pregnancies were continued, whereas all other mosaic pregnancies (100%) were continued (P = 0.004). Of 32 SCA cases counselled by a perinatologist, 66% (21 of 32) were continued. In contrast, 36% (nine of 25) of cases counselled by a general obstetrician were continued, a barely significant difference (P = 0.048). More couples chose to continue pregnancies in recent years. Conclusion: Genetic counselling by well-trained specialists is valuable, and the trend towards fewer terminations at our centre suggests improved parental knowledge of pathology associated with SCA.
KW - Genetic counselling
KW - Prenatal diagnosis
KW - Sex chromosome abnormality
UR - http://www.scopus.com/inward/record.url?scp=41149118424&partnerID=8YFLogxK
U2 - 10.1111/j.1479-828X.2008.00828.x
DO - 10.1111/j.1479-828X.2008.00828.x
M3 - 文章
C2 - 18366488
AN - SCOPUS:41149118424
SN - 0004-8666
VL - 48
SP - 155
EP - 159
JO - Australian and New Zealand Journal of Obstetrics and Gynaecology
JF - Australian and New Zealand Journal of Obstetrics and Gynaecology
IS - 2
ER -