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Pathogen recognition or homeostasis? APC receptor functions in innate immunity

  • University of Oxford

Research output: Contribution to journalJournal Article peer-review

26 Scopus citations

Abstract

Myeloid cells (macrophages, neutrophils, dendritic cells) express a repertoire of plasma membrane receptors able to recognize all classes of macromolecules. The concept of pattern recognition has emphasized microbial ligands and host defence. However, these receptors play a broader role in tissue homeostasis within multicellular hosts, clearing the extracellular environment of potential undesirable ligands arising endogenously as well as from without. This article will evaluate one of the paradigms that underlie innate immunity.

Original languageEnglish
Pages (from-to)603-607
Number of pages5
JournalComptes Rendus - Biologies
Volume327
Issue number6
DOIs
StatePublished - 06 2004
Externally publishedYes

Keywords

  • Dendritic cells
  • Lectins
  • Macrophages
  • Pathogens
  • Receptors
  • Scavenger receptors

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