Pemphigus vegetans occurring in a split-thickness skin graft

BACKGROUND. Pemphigus vegetans, a variant of pemphigus vulgaris, most commonly occurs in the flexural area. OBJECTIVE. To describe an unusual case of pemphigus vegetans occurring in a skin graft recipient site and to discuss the possible etiology. METHODS. We present a 41-year-old man who developed vegetating plaques from the graft recipient site of his left leg for 8 months. RESULTS. Based on the histopathologic findings of a skin biopsy, this case was diagnosed as pemphigus vegetans. The patient's condition was successfully treated with systemic corticosteroids and acitretin. CONCLUSION. Our case is unique in its presentation of pemphigus vegetans shortly after a split-thickness skin graft. Physicians should be aware of this entity while differentiating cutaneous lesions arising from a skin graft.