Pentatrichomonas hominis: Purine salvage pathway

Petrus Tang*, Hsin Sheng Lo

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations


1. 1. Pentatrichomonas hominis was found incapable of de novo synthesis of purines. 2. 2. Pentatrichomonas hominis can salvage adenine, guanine, hypoxanthine, adenosine, guanosine and inosine, but not xanthine for the synthesis of nucleotides. 3. 3. HPLC tracing of radiolabelled purines or purine nucleosides revealed that adenine, adenosine and hypoxanthine are incorporatd into adenine nucleotides and IMP through a similar channel while guanine and guanosine are salvaged into guanine nucleotides via another route. There appears to be no direct interconversion between adenine and guanine nucleotides. Interconversion between AMP and IMP was observed. 4. 4. Assays of purine salvage enzymes revealed that P. hominis possesses adenosine kinase; adenosine, guanosine and inosine phosphotransferases; adenosine, guanosine and inosine phosphorylases and AMP deaminase.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Issue number2
StatePublished - 1988
Externally publishedYes


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