Perforin-mediated myocardial damage in acute myocarditis

L. H.Y. Young*, S. V. Joag, L. M. Zheng, J. D.E. Young, C. P. Lee, Y. S. Lee

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

79 Scopus citations

Abstract

Endomyocardial specimens were obtained from 7 patients with acute myocarditis. Immunohistochemical examination of the mononuclear infiltrate showed mainly cytotoxic T lymphocytes and natural killer cells. Perforin (a pore-forming protein found in cytotoxic lymphocytes) was identified in this myocardial lymphocytic infiltrate and electron microscopy showed myocardial cell damage that may have been associated with these perforin containing lymphocytes. The results indicate that in acute idiopathic and viral myocarditis, myocardial damage may be due to the action of perforin-secretinq lymphocytes.

Original languageEnglish
Pages (from-to)1019-1021
Number of pages3
JournalThe Lancet
Volume336
Issue number8722
DOIs
StatePublished - 27 10 1990
Externally publishedYes

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