Perioperative topical ascorbic acid for the prevention of phacoemulsification-related corneal endothelial damage: Two case reports and review of literature

Chia Yi Lee, Hung Ta Chen, Yi Jen Hsueh, Hung Chi Chen*, Chieh Cheng Huang, Yaa Jyuhn James Meir, Chao Min Cheng, Wei Chi Wu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

8 Scopus citations

Abstract

BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid (AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial decompensation. CASE SUMMARY Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy (Patient 1) and endotheliitis (Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity (BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two years. CONCLUSION Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery.

Original languageEnglish
Pages (from-to)642-649
Number of pages8
JournalWorld Journal of Clinical Cases
Volume7
Issue number5
DOIs
StatePublished - 01 03 2019

Bibliographical note

Publisher Copyright:
© The Author(s) 2019.

Keywords

  • Ascorbic acid
  • Case report
  • Endotheliitis
  • Fuchs corneal endothelial dystrophy
  • Human corneal endothelial cell
  • Phacoemulsification

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