Peripheral vascular endothelial dysfunction in central serous chorioretinopathy

Nan Kai Wang, Yun Fu, Jung Pan Wang, Eugene Yu Chan Kang, An Lun Wu, Yun Ju Tseng, Lung Kun Yeh, Kuan Jen Chen, Wei Chi Wu, Wan Jing Ho*, Chi Chun Lai

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations


PURPOSE. To explore the pathophysiology of central serous chorioretinopathy (CSC) by comparing peripheral vascular endothelium function in patients with CSC and control subjects. METHODS. This study included 34 patients with CSC who attended the Department of Ophthalmology and 34 healthy age- and sex-matched healthy control subjects from a routine physical check-up population. Endothelium-dependent flow-mediated vasodilation (FMD) and endothelium-independent nitroglycerine-mediated vasodilation (NMD) were measured using high-resolution, two-dimensional ultrasonographic imaging of the brachial artery. Blood samples were taken to test serum glucose, cholesterol, triglyceride, alanine aminotransferase, uric acid, and high-sensitivity C-reactive protein (hs-CRP) levels. RESULTS. The mean age of patients with CSC was 44.0 years (SD ±8.1) and that of controls 46.1 years (±9.9) (P = 0.352). There were no significant differences between groups in serum biochemical data, including serum glucose, alanine aminotransferase, uric acid, cholesterol, triglyceride, and hs-CRP. FMD was significantly impaired in patients with CSC compared with control subjects (CSC: 4.62 ± 1.96, control: 7.52 ± 2.63, P < 0.001), whereas NMD did not differ significantly between the two groups (CSC: 16.31 ± 5.60, control: 16.22 ± 5.56, P = 0.950). CONCLUSIONS. This study demonstrated impaired FMD in patients with CSC and the results have provided evidence of peripheral endothelium dysfunction associated with CSC in patients.

Original languageEnglish
Pages (from-to)4524-4529
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number11
StatePublished - 09 2017

Bibliographical note

Publisher Copyright:
© 2017 The Authors.


  • Central serous chorioretinopathy
  • Endothelium
  • Ultrasonography


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