Peroxidase mimetic nanozymes in cancer phototherapy: Progress and perspectives

Suresh Thangudu; Chia Hao Su

doi:10.3390/biom11071015

Peroxidase mimetic nanozymes in cancer phototherapy: Progress and perspectives

Suresh Thangudu, Chia Hao Su^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical appli-cations. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H₂O₂) to oxygen (O₂) and peroxidase (POD) mimetic nanozymes converts endogenous H₂O₂ to water (H₂O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

Original language	English
Article number	1015
Journal	Biomolecules
Volume	11
Issue number	7
DOIs	https://doi.org/10.3390/biom11071015
State	Published - 07 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cancer therapy
Dual enzyme
Enzyme mimetic
Nanomaterials
Nanozymes
Peroxidase mimetic
Phototherapy
Single atom
Theranostics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biom11071015

Cite this

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title = "Peroxidase mimetic nanozymes in cancer phototherapy: Progress and perspectives",

abstract = "Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical appli-cations. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.",

keywords = "Cancer therapy, Dual enzyme, Enzyme mimetic, Nanomaterials, Nanozymes, Peroxidase mimetic, Phototherapy, Single atom, Theranostics",

author = "Suresh Thangudu and Su, {Chia Hao}",

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year = "2021",

month = jul,

doi = "10.3390/biom11071015",

language = "英语",

volume = "11",

journal = "Biomolecules",

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T1 - Peroxidase mimetic nanozymes in cancer phototherapy

T2 - Progress and perspectives

AU - Thangudu, Suresh

AU - Su, Chia Hao

PY - 2021/7

Y1 - 2021/7

N2 - Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical appli-cations. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

AB - Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical appli-cations. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

KW - Cancer therapy

KW - Dual enzyme

KW - Enzyme mimetic

KW - Nanomaterials

KW - Nanozymes

KW - Peroxidase mimetic

KW - Phototherapy

KW - Single atom

KW - Theranostics

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U2 - 10.3390/biom11071015

DO - 10.3390/biom11071015

M3 - 文献综述

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AN - SCOPUS:85109332218

SN - 2218-273X

VL - 11

JO - Biomolecules

JF - Biomolecules

IS - 7

M1 - 1015

ER -

Peroxidase mimetic nanozymes in cancer phototherapy: Progress and perspectives

Abstract

Bibliographical note

Keywords

UN SDGs

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