Peroxidase mimetic nanozymes in cancer phototherapy: Progress and perspectives

Suresh Thangudu, Chia Hao Su*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical appli-cations. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

Original languageEnglish
Article number1015
Issue number7
StatePublished - 07 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Cancer therapy
  • Dual enzyme
  • Enzyme mimetic
  • Nanomaterials
  • Nanozymes
  • Peroxidase mimetic
  • Phototherapy
  • Single atom
  • Theranostics


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