Abstract
In 500 children aged ≤10 years after 13-valent pneumococcal conjugate vaccine (PCV)13 immunisation in different schedules, serotypes 19A-specific and 19F-specific immunoglobulin G (IgG) were predicted to persist above 0.35 μg/mL for ≥10 years in all groups, likely due to PCV13-induced memory with natural boosting from residual diseases and colonisation. Generally, serotype-specific IgG could persist above 0.35 μg/mL longer (≥5 years) in the catch-up group than in the 2+1 and 3+1 immunisation groups. 14.5% of the carriage isolates belonged to PCV13 serotypes; statistical analysis revealed that a high serum IgG level (>10.96 μg/mL) will be required to eliminate the point-prevalence nasopharyngeal carriage of serotype 19A.
| Original language | English |
|---|---|
| Pages (from-to) | 689-692 |
| Number of pages | 4 |
| Journal | Thorax |
| Volume | 75 |
| Issue number | 8 |
| DOIs | |
| State | Published - 01 08 2020 |
Bibliographical note
Publisher Copyright:© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Keywords
- bacterial infection
- clinical epidemiology
- infection control
- paediatric lung disaese
- pneumonia
- respiratory infection
