Persistence of lower vocal intensity in vocal fold paralysis with cricothyroid impairment after hyaluronate injection

Kuo Cheng Liu, Yi An Lu, Hsiu Feng Chuang, Li Jen Hsin, Wan Ni Lin, Alice M.K. Wong, Yu Cheng Pei*, Tuan Jen Fang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review


Background: Unilateral vocal fold paralysis (UVFP) affects the glottal gap, voice, and aerodynamics, whereas injection laryngoplasty (IL) using hyaluronate is an effective treatment for UVFP by decreasing the glottal gap to improve voice. Previous studies have shown that the involvement of cricothyroid (CT) muscle in UVFP patients further affects patients' aerodynamics, but it remains unclear whether the difference remains after IL. This study investigates whether the aerodynamic features observed in UVFP with CT involvement could still be observed after IL. Methods: This study recruited UVFP patients with dysphonia, and IL was performed within 6 months of initial symptoms. All subjects received assessments including videolaryngoscopy, voice analysis, and aerodynamics at three time points: before IL, 1 month after IL, and 6 months after IL. The glottal gap, voice, and aerodynamics between patients with and without CT involvement (the CT+ and CT− groups) were compared, and the change (Δ) before and after IL and repeated-measures analysis of variance (ANOVA) were also compared between the two groups. Result: A total of 71 patients with UVFP (22 in the CT+ group and 49 in the CT− group) were analyzed. After IL, the CT+ group showed a lower sound pressure level (SPL), higher Δair pressure, and smaller Δaerodynamic power than the CT− group. Conclusion: The CT+ group had a lower SPL, even after elevating air pressure to attempt to achieve a higher vocal intensity. The results suggest that although closure of the glottal gap was achieved by IL, the CT+ group still had a lower loudness and needed to sustain a higher peak air pressure when producing voice. Level of evidence: Level 4.

Original languageEnglish
Pages (from-to)1922-1929
Number of pages8
JournalLaryngoscope Investigative Otolaryngology
Issue number6
StatePublished - 12 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.


  • aerodynamics
  • air pressure
  • cricothyroid
  • injection laryngoplasty
  • unilateral vocal fold paralysis


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