Phagocytosis: An Immunobiologic Process

Siamon Gordon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

622 Scopus citations

Abstract

It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and established a firm basis for our understanding of inflammation and tissue homeostasis. The past century has brought improved tools of cellular and molecular biology to the study of phagocytosis and its contribution to physiological and pathological processes, including receptor function in innate and acquired immunity. In this review, I assess our present knowledge and consider opportunities for future research and therapeutic targeting.

Original languageEnglish
Pages (from-to)463-475
Number of pages13
JournalImmunity
Volume44
Issue number3
DOIs
StatePublished - 15 03 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

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