Pharmacogenomics and Cutaneous Adverse Drug Reactions

Ren You Pan; Chun Bing Chen; Wen Hung Chung

doi:10.1007/978-981-13-1489-6_3

Pharmacogenomics and Cutaneous Adverse Drug Reactions

Ren You Pan
, Chun Bing Chen
, Wen Hung Chung^*

^*Corresponding author for this work

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Cutaneous adverse drug reactions (cADRs) are unpredictable and may range from mild maculopapular exanthema (MPE) to life-threatening severe cutaneous adverse drug reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Increasing pharmacogenomic studies showed specific HLA alleles are strongly associated with cADRs. The pathogenic checkpoints of cADRs include genetic polymorphisms affecting the immune synapse of HLA/drugs/T cell receptor interactions, specific HLA loci, T cell-mediated responses, and drug metabolism. Recently, pharmacogenomic screening for specific HLA alleles or high-risk genes prior to drug prescriptions to prevent cADRs has been widely implemented in clinical practice.

Original language	English
Title of host publication	Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions
Subtitle of host publication	Current and Future Trends
Publisher	Springer Singapore
Pages	39-53
Number of pages	15
ISBN (Electronic)	9789811314896
ISBN (Print)	9789811314889
DOIs	https://doi.org/10.1007/978-981-13-1489-6_3
State	Published - 01 01 2018

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2019.

Keywords

Cutaneous adverse drug reactions (cADRs)
Drug reaction with eosinophilia and systemic symptoms (DRESS)
Human leukocyte antigen (HLA)
Stevens-Johnson syndrome (SJS)
T cell receptors (TCR)
Toxic epidermal necrolysis (TEN)

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10.1007/978-981-13-1489-6_3

Cite this

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title = "Pharmacogenomics and Cutaneous Adverse Drug Reactions",

abstract = "Cutaneous adverse drug reactions (cADRs) are unpredictable and may range from mild maculopapular exanthema (MPE) to life-threatening severe cutaneous adverse drug reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Increasing pharmacogenomic studies showed specific HLA alleles are strongly associated with cADRs. The pathogenic checkpoints of cADRs include genetic polymorphisms affecting the immune synapse of HLA/drugs/T cell receptor interactions, specific HLA loci, T cell-mediated responses, and drug metabolism. Recently, pharmacogenomic screening for specific HLA alleles or high-risk genes prior to drug prescriptions to prevent cADRs has been widely implemented in clinical practice.",

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AU - Chen, Chun Bing

AU - Chung, Wen Hung

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N2 - Cutaneous adverse drug reactions (cADRs) are unpredictable and may range from mild maculopapular exanthema (MPE) to life-threatening severe cutaneous adverse drug reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Increasing pharmacogenomic studies showed specific HLA alleles are strongly associated with cADRs. The pathogenic checkpoints of cADRs include genetic polymorphisms affecting the immune synapse of HLA/drugs/T cell receptor interactions, specific HLA loci, T cell-mediated responses, and drug metabolism. Recently, pharmacogenomic screening for specific HLA alleles or high-risk genes prior to drug prescriptions to prevent cADRs has been widely implemented in clinical practice.

AB - Cutaneous adverse drug reactions (cADRs) are unpredictable and may range from mild maculopapular exanthema (MPE) to life-threatening severe cutaneous adverse drug reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Increasing pharmacogenomic studies showed specific HLA alleles are strongly associated with cADRs. The pathogenic checkpoints of cADRs include genetic polymorphisms affecting the immune synapse of HLA/drugs/T cell receptor interactions, specific HLA loci, T cell-mediated responses, and drug metabolism. Recently, pharmacogenomic screening for specific HLA alleles or high-risk genes prior to drug prescriptions to prevent cADRs has been widely implemented in clinical practice.

KW - Cutaneous adverse drug reactions (cADRs)

KW - Drug reaction with eosinophilia and systemic symptoms (DRESS)

KW - Human leukocyte antigen (HLA)

KW - Stevens-Johnson syndrome (SJS)

KW - T cell receptors (TCR)

KW - Toxic epidermal necrolysis (TEN)

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M3 - 章节

AN - SCOPUS:85150574784

SN - 9789811314889

SP - 39

EP - 53

BT - Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions

PB - Springer Singapore

ER -

Pharmacogenomics and Cutaneous Adverse Drug Reactions

Abstract

Bibliographical note

Keywords

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