Pharmacotherapeutic options for hepatitis B

Yi Cheng Chen, Yun Fan Liaw*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Introduction: Hepatitis B virus (HBV) is the driving force of disease progression in chronic hepatitis B. Patients with active HBV replication and/or significant liver disease require timely treatment. Currently, pegylated interferon-α (PEG IFN), entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are the preferred first-line drugs.Areas covered: A finite course IFN-based therapy has modest response and may reduce cirrhosis or hepatocellular carcinoma development. Nucleos(t)ide analogs (Nuc) have excellent safety profile, cumulative or maintained response and long-term efficacy in terms of reduction or reversal of fibrosis, decrease in development of cirrhosis and its adverse sequalae. The optimal duration of Nuc therapy is unknown and a feasible stopping rule with off-therapy monitoring plan has been developed.Expert opinion: Choosing a drug to initiate therapy in a right patient at a right time should be primarily based on the prospect and likelihood for improved outcomes. Nuc is the only choice for patients with hepatic decompensation, pregnant women and those about to receive immune/chemotherapy or organ transplantation. IFN-based therapy is preferred in patients with compensated liver disease, particularly in young patients, females of childbearing age. The development of new drugs and new strategies is the highest priority in further improving the outcomes of treatment.

Original languageEnglish
Pages (from-to)355-367
Number of pages13
JournalExpert Opinion on Pharmacotherapy
Volume17
Issue number3
DOIs
StatePublished - 11 02 2016

Bibliographical note

Publisher Copyright:
© 2015 Taylor & Francis.

Keywords

  • Chronic hepatitis B
  • Cirrhosis
  • Entecavir
  • Pegylated interferon alfa
  • Tenofovir disoproxil fumarate

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