Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis

Shin Lei Peng; Fu Nien Wang; Tao Chieh Yang; Jee Ching Hsu; Yi Chun Wu; Hsu Hsia Peng

doi:10.1016/j.mri.2015.12.026

Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis

Shin Lei Peng
, Fu Nien Wang
, Tao Chieh Yang
, Jee Ching Hsu
, Yi Chun Wu
, Hsu Hsia Peng^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

Purpose: To measure wall shear stress (WSS) in the common carotid arteries (CCA) of a spontaneously hypertensive rat (SHR) model and a normotensive Wistar Kyoto rat (WKY) model by 2D phase-contrast magnetic resonance imaging (PC-MRI). Materials and methods: PC-MRI was performed on 7 SHR and 7 WKY at ages of 4 and 7 months at a 7 T scanner. Images in the middle CCA (CCA_mid) and in the bifurcation of CCA (CCA_bifur) were acquired. The WSS values for differentiating characteristics between two models were calculated. Further, its location-specific change, regional distribution along the CCA circumference, and the reproducibility were evaluated. Results: In the 4-month-old rats, SHR showed lower temporal averaged WSS (WSS_avg) and peak systolic WSS (WSS_s) in the CCA_bifur in comparison with WKY (WSS_avg: 0.95 ± 0.18 vs. 1.30 ± 0.36 N/m² (P < 0.01); WSS_s: 1.68 ± 0.70 vs. 3.22 ± 2.49 N/m² (P < 0.05)). We observed the same trends in the 7-month-old rats. In the SHR model, the WSS_avg was lower in the CCA_bifur than in the CCA_mid. The regional distribution of WSS_avg along the circumference of CCA showed lower values in WKY, particularly in posterior segments of CCA_bifur. The intra-observer, intra-scan and inter-scan reproducibility was acceptable and the disagreements were ranged from -0.05 to 0.06 N/m². Conclusion: This study evaluated WSS in SHR and WKY models by 2D PC-MRI. High reproducibility analyses further indicated the reliability of measurements of WSS in the CCA of SHR and WKY models using PC-MRI at 7 T.

Original language	English
Pages (from-to)	624-631
Number of pages	8
Journal	Magnetic Resonance Imaging
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.mri.2015.12.026
State	Published - 01 06 2016

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Flow measurement
Phase-contrast magnetic resonance imaging
Spontaneously hypertensive rat
Wall shear stress

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10.1016/j.mri.2015.12.026

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Peng, S. L., Wang, F. N., Yang, T. C., Hsu, J. C., Wu, Y. C., & Peng, H. H. (2016). Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis. Magnetic Resonance Imaging, 34(5), 624-631. https://doi.org/10.1016/j.mri.2015.12.026

Peng, Shin Lei ; Wang, Fu Nien ; Yang, Tao Chieh et al. / Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T : Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis. In: Magnetic Resonance Imaging. 2016 ; Vol. 34, No. 5. pp. 624-631.

@article{8fa8d95c3cee4716952cb6fd0395a64c,

title = "Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis",

abstract = "Purpose: To measure wall shear stress (WSS) in the common carotid arteries (CCA) of a spontaneously hypertensive rat (SHR) model and a normotensive Wistar Kyoto rat (WKY) model by 2D phase-contrast magnetic resonance imaging (PC-MRI). Materials and methods: PC-MRI was performed on 7 SHR and 7 WKY at ages of 4 and 7 months at a 7 T scanner. Images in the middle CCA (CCAmid) and in the bifurcation of CCA (CCAbifur) were acquired. The WSS values for differentiating characteristics between two models were calculated. Further, its location-specific change, regional distribution along the CCA circumference, and the reproducibility were evaluated. Results: In the 4-month-old rats, SHR showed lower temporal averaged WSS (WSSavg) and peak systolic WSS (WSSs) in the CCAbifur in comparison with WKY (WSSavg: 0.95 ± 0.18 vs. 1.30 ± 0.36 N/m2 (P < 0.01); WSSs: 1.68 ± 0.70 vs. 3.22 ± 2.49 N/m2 (P < 0.05)). We observed the same trends in the 7-month-old rats. In the SHR model, the WSSavg was lower in the CCAbifur than in the CCAmid. The regional distribution of WSSavg along the circumference of CCA showed lower values in WKY, particularly in posterior segments of CCAbifur. The intra-observer, intra-scan and inter-scan reproducibility was acceptable and the disagreements were ranged from -0.05 to 0.06 N/m2. Conclusion: This study evaluated WSS in SHR and WKY models by 2D PC-MRI. High reproducibility analyses further indicated the reliability of measurements of WSS in the CCA of SHR and WKY models using PC-MRI at 7 T.",

keywords = "Flow measurement, Phase-contrast magnetic resonance imaging, Spontaneously hypertensive rat, Wall shear stress",

author = "Peng, \{Shin Lei\} and Wang, \{Fu Nien\} and Yang, \{Tao Chieh\} and Hsu, \{Jee Ching\} and Wu, \{Yi Chun\} and Peng, \{Hsu Hsia\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.mri.2015.12.026",

language = "英语",

volume = "34",

pages = "624--631",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

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}

Peng, SL, Wang, FN, Yang, TC, Hsu, JC, Wu, YC & Peng, HH 2016, 'Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis', Magnetic Resonance Imaging, vol. 34, no. 5, pp. 624-631. https://doi.org/10.1016/j.mri.2015.12.026

Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis. / Peng, Shin Lei; Wang, Fu Nien; Yang, Tao Chieh et al.
In: Magnetic Resonance Imaging, Vol. 34, No. 5, 01.06.2016, p. 624-631.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T

T2 - Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis

AU - Peng, Shin Lei

AU - Wang, Fu Nien

AU - Yang, Tao Chieh

AU - Hsu, Jee Ching

AU - Wu, Yi Chun

AU - Peng, Hsu Hsia

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Purpose: To measure wall shear stress (WSS) in the common carotid arteries (CCA) of a spontaneously hypertensive rat (SHR) model and a normotensive Wistar Kyoto rat (WKY) model by 2D phase-contrast magnetic resonance imaging (PC-MRI). Materials and methods: PC-MRI was performed on 7 SHR and 7 WKY at ages of 4 and 7 months at a 7 T scanner. Images in the middle CCA (CCAmid) and in the bifurcation of CCA (CCAbifur) were acquired. The WSS values for differentiating characteristics between two models were calculated. Further, its location-specific change, regional distribution along the CCA circumference, and the reproducibility were evaluated. Results: In the 4-month-old rats, SHR showed lower temporal averaged WSS (WSSavg) and peak systolic WSS (WSSs) in the CCAbifur in comparison with WKY (WSSavg: 0.95 ± 0.18 vs. 1.30 ± 0.36 N/m2 (P < 0.01); WSSs: 1.68 ± 0.70 vs. 3.22 ± 2.49 N/m2 (P < 0.05)). We observed the same trends in the 7-month-old rats. In the SHR model, the WSSavg was lower in the CCAbifur than in the CCAmid. The regional distribution of WSSavg along the circumference of CCA showed lower values in WKY, particularly in posterior segments of CCAbifur. The intra-observer, intra-scan and inter-scan reproducibility was acceptable and the disagreements were ranged from -0.05 to 0.06 N/m2. Conclusion: This study evaluated WSS in SHR and WKY models by 2D PC-MRI. High reproducibility analyses further indicated the reliability of measurements of WSS in the CCA of SHR and WKY models using PC-MRI at 7 T.

AB - Purpose: To measure wall shear stress (WSS) in the common carotid arteries (CCA) of a spontaneously hypertensive rat (SHR) model and a normotensive Wistar Kyoto rat (WKY) model by 2D phase-contrast magnetic resonance imaging (PC-MRI). Materials and methods: PC-MRI was performed on 7 SHR and 7 WKY at ages of 4 and 7 months at a 7 T scanner. Images in the middle CCA (CCAmid) and in the bifurcation of CCA (CCAbifur) were acquired. The WSS values for differentiating characteristics between two models were calculated. Further, its location-specific change, regional distribution along the CCA circumference, and the reproducibility were evaluated. Results: In the 4-month-old rats, SHR showed lower temporal averaged WSS (WSSavg) and peak systolic WSS (WSSs) in the CCAbifur in comparison with WKY (WSSavg: 0.95 ± 0.18 vs. 1.30 ± 0.36 N/m2 (P < 0.01); WSSs: 1.68 ± 0.70 vs. 3.22 ± 2.49 N/m2 (P < 0.05)). We observed the same trends in the 7-month-old rats. In the SHR model, the WSSavg was lower in the CCAbifur than in the CCAmid. The regional distribution of WSSavg along the circumference of CCA showed lower values in WKY, particularly in posterior segments of CCAbifur. The intra-observer, intra-scan and inter-scan reproducibility was acceptable and the disagreements were ranged from -0.05 to 0.06 N/m2. Conclusion: This study evaluated WSS in SHR and WKY models by 2D PC-MRI. High reproducibility analyses further indicated the reliability of measurements of WSS in the CCA of SHR and WKY models using PC-MRI at 7 T.

KW - Flow measurement

KW - Phase-contrast magnetic resonance imaging

KW - Spontaneously hypertensive rat

KW - Wall shear stress

UR - https://www.scopus.com/pages/publications/84960968621

U2 - 10.1016/j.mri.2015.12.026

DO - 10.1016/j.mri.2015.12.026

M3 - 文章

C2 - 26712655

AN - SCOPUS:84960968621

SN - 0730-725X

VL - 34

SP - 624

EP - 631

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 5

ER -

Peng SL, Wang FN, Yang TC, Hsu JC, Wu YC, Peng HH. Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis. Magnetic Resonance Imaging. 2016 Jun 1;34(5):624-631. doi: 10.1016/j.mri.2015.12.026

Phase-contrast magnetic resonance imaging for the evaluation of wall shear stress in the common carotid artery of a spontaneously hypertensive rat model at 7 T: Location-specific change, regional distribution along the vascular circumference, and reproducibility analysis

Abstract

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Keywords

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