Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone

Fu Yuan Tsai; Shwu Bin Lin; Shwu Chen Tsay; Wei Chen Lin; Chia Lin Hsieh; Shih Hsien Chuang; Lou Sing Kan; Jih Ru Hwu

doi:10.1016/S0040-4039(01)00963-7

Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone

Fu Yuan Tsai, Shwu Bin Lin, Shwu Chen Tsay, Wei Chen Lin, Chia Lin Hsieh, Shih Hsien Chuang, Lou Sing Kan^*, Jih Ru Hwu

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

6 Scopus citations

Abstract

Irradiation, with 350 nm UV light, of specially designed and synthesized single- and double-stranded oligodeoxyribonucleotides in the presence of 3-(p-tolylamino)-1,5-azulenequinone produced fragments resulting from the cleavage at the deoxyguanosine residue only. The cleaving efficiency was greater for a single strand than a double helix. The efficiency was increased for a less stable double helix, or while the deoxyguanosine residue therein was located at a bulge, at a hairpin loop, or towards the end of the helix.

Original language	English
Pages (from-to)	5733-5735
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	33
DOIs	https://doi.org/10.1016/S0040-4039(01)00963-7
State	Published - 13 08 2001
Externally published	Yes

Keywords

Azulenequinone
DNA cleavage
Deoxyguanosine
Photochemistry
Site-specificity

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10.1016/S0040-4039(01)00963-7

Cite this

@article{fcce8391a0754d7897ca73edeb71da0b,

title = "Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone",

abstract = "Irradiation, with 350 nm UV light, of specially designed and synthesized single- and double-stranded oligodeoxyribonucleotides in the presence of 3-(p-tolylamino)-1,5-azulenequinone produced fragments resulting from the cleavage at the deoxyguanosine residue only. The cleaving efficiency was greater for a single strand than a double helix. The efficiency was increased for a less stable double helix, or while the deoxyguanosine residue therein was located at a bulge, at a hairpin loop, or towards the end of the helix.",

keywords = "Azulenequinone, DNA cleavage, Deoxyguanosine, Photochemistry, Site-specificity",

author = "Tsai, \{Fu Yuan\} and Lin, \{Shwu Bin\} and Tsay, \{Shwu Chen\} and Lin, \{Wei Chen\} and Hsieh, \{Chia Lin\} and Chuang, \{Shih Hsien\} and Kan, \{Lou Sing\} and Hwu, \{Jih Ru\}",

year = "2001",

month = aug,

day = "13",

doi = "10.1016/S0040-4039(01)00963-7",

language = "英语",

volume = "42",

pages = "5733--5735",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "33",

}

TY - JOUR

T1 - Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone

AU - Tsai, Fu Yuan

AU - Lin, Shwu Bin

AU - Tsay, Shwu Chen

AU - Lin, Wei Chen

AU - Hsieh, Chia Lin

AU - Chuang, Shih Hsien

AU - Kan, Lou Sing

AU - Hwu, Jih Ru

PY - 2001/8/13

Y1 - 2001/8/13

N2 - Irradiation, with 350 nm UV light, of specially designed and synthesized single- and double-stranded oligodeoxyribonucleotides in the presence of 3-(p-tolylamino)-1,5-azulenequinone produced fragments resulting from the cleavage at the deoxyguanosine residue only. The cleaving efficiency was greater for a single strand than a double helix. The efficiency was increased for a less stable double helix, or while the deoxyguanosine residue therein was located at a bulge, at a hairpin loop, or towards the end of the helix.

AB - Irradiation, with 350 nm UV light, of specially designed and synthesized single- and double-stranded oligodeoxyribonucleotides in the presence of 3-(p-tolylamino)-1,5-azulenequinone produced fragments resulting from the cleavage at the deoxyguanosine residue only. The cleaving efficiency was greater for a single strand than a double helix. The efficiency was increased for a less stable double helix, or while the deoxyguanosine residue therein was located at a bulge, at a hairpin loop, or towards the end of the helix.

KW - Azulenequinone

KW - DNA cleavage

KW - Deoxyguanosine

KW - Photochemistry

KW - Site-specificity

UR - https://www.scopus.com/pages/publications/0035855369

U2 - 10.1016/S0040-4039(01)00963-7

DO - 10.1016/S0040-4039(01)00963-7

M3 - 文章

AN - SCOPUS:0035855369

SN - 0040-4039

VL - 42

SP - 5733

EP - 5735

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Photochemical cleavage of single- and double-stranded oligonucleotides by 3-(p-tolylamino)-1,5-azulenequinone

Abstract

Keywords

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