phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development

Haiwei Pi; Shao Kuei Huang; Chiou Yang Tang; Y. Henry Sun; Cheng Ting Chien

doi:10.1073/pnas.0306010101

phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development

Haiwei Pi, Shao Kuei Huang, Chiou Yang Tang, Y. Henry Sun, Cheng Ting Chien^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

31 Scopus citations

Abstract

Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.

Original language	English
Pages (from-to)	8378-8383
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	101
Issue number	22
DOIs	https://doi.org/10.1073/pnas.0306010101
State	Published - 01 06 2004
Externally published	Yes

Keywords

Basic helix-loop-helix
E3 ligase
Neurogenesis
Senseless

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10.1073/pnas.0306010101

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title = "phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development",

abstract = "Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.",

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author = "Haiwei Pi and Huang, {Shao Kuei} and Tang, {Chiou Yang} and Sun, {Y. Henry} and Chien, {Cheng Ting}",

year = "2004",

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doi = "10.1073/pnas.0306010101",

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T1 - phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development

AU - Pi, Haiwei

AU - Huang, Shao Kuei

AU - Tang, Chiou Yang

AU - Sun, Y. Henry

AU - Chien, Cheng Ting

PY - 2004/6/1

Y1 - 2004/6/1

N2 - Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.

AB - Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.

KW - Basic helix-loop-helix

KW - E3 ligase

KW - Neurogenesis

KW - Senseless

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U2 - 10.1073/pnas.0306010101

DO - 10.1073/pnas.0306010101

M3 - 文章

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SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development

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Keywords

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