Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.

Yu Chia Chang; Liang Mou Kuo; Tsong Long Hwang; Jessica Yeh; Zhi Hong Wen; Lee Shing Fang; Yang Chang Wu; Chan Shing Lin; Jyh Horng Sheu; Ping Jyun Sung

doi:10.3390/md14010012

Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.

Yu Chia Chang, Liang Mou Kuo, Tsong Long Hwang, Jessica Yeh, Zhi Hong Wen, Lee Shing Fang, Yang Chang Wu, Chan Shing Lin^*, Jyh Horng Sheu, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

Original language	English
Article number	12
Journal	Marine Drugs
Volume	14
Issue number	1
DOIs	https://doi.org/10.3390/md14010012
State	Published - 01 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI.

Keywords

Anti-inflammatory
Cytotoxicity
Elastase
Gorgonian
HSCs
Pinnigorgia
Secosterol
Superoxide anion

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title = "Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.",

abstract = "Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).",

keywords = "Anti-inflammatory, Cytotoxicity, Elastase, Gorgonian, HSCs, Pinnigorgia, Secosterol, Superoxide anion",

author = "Chang, {Yu Chia} and Kuo, {Liang Mou} and Hwang, {Tsong Long} and Jessica Yeh and Wen, {Zhi Hong} and Fang, {Lee Shing} and Wu, {Yang Chang} and Lin, {Chan Shing} and Sheu, {Jyh Horng} and Sung, {Ping Jyun}",

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AU - Chang, Yu Chia

AU - Kuo, Liang Mou

AU - Hwang, Tsong Long

AU - Yeh, Jessica

AU - Wen, Zhi Hong

AU - Fang, Lee Shing

AU - Wu, Yang Chang

AU - Lin, Chan Shing

AU - Sheu, Jyh Horng

AU - Sung, Ping Jyun

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AB - Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

KW - Anti-inflammatory

KW - Cytotoxicity

KW - Elastase

KW - Gorgonian

KW - HSCs

KW - Pinnigorgia

KW - Secosterol

KW - Superoxide anion

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U2 - 10.3390/md14010012

DO - 10.3390/md14010012

M3 - 文章

C2 - 26751457

AN - SCOPUS:84955478513

SN - 1660-3397

VL - 14

JO - Marine Drugs

JF - Marine Drugs

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ER -

Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.

Abstract

Bibliographical note

Keywords

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