Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.

Yu Chia Chang; Liang Mou Kuo; Tsong Long Hwang; Jessica Yeh; Zhi Hong Wen; Lee Shing Fang; Yang Chang Wu; Chan Shing Lin; Jyh Horng Sheu; Ping Jyun Sung

doi:10.3390/md14010012

Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.

Yu Chia Chang
, Liang Mou Kuo
, Tsong Long Hwang
, Jessica Yeh
, Zhi Hong Wen
, Lee Shing Fang
, Yang Chang Wu
, Chan Shing Lin^*
, Jyh Horng Sheu
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

National Sun Yat-sen University
National Museum of Marine Biology and Aquarium, Taiwan
Chang Gung University
Chang Gung Memorial Hospital
Cheng Shiu University Taiwan
China Medical University Taichung
Kaohsiung Medical University
National Dong Hwa University

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

Original language	English
Article number	12
Journal	Marine Drugs
Volume	14
Issue number	1
DOIs	https://doi.org/10.3390/md14010012
State	Published - 01 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI.

Keywords

Anti-inflammatory
Cytotoxicity
Elastase
Gorgonian
HSCs
Pinnigorgia
Secosterol
Superoxide anion

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10.3390/md14010012

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title = "Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.",

abstract = "Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).",

keywords = "Anti-inflammatory, Cytotoxicity, Elastase, Gorgonian, HSCs, Pinnigorgia, Secosterol, Superoxide anion",

author = "Chang, \{Yu Chia\} and Kuo, \{Liang Mou\} and Hwang, \{Tsong Long\} and Jessica Yeh and Wen, \{Zhi Hong\} and Fang, \{Lee Shing\} and Wu, \{Yang Chang\} and Lin, \{Chan Shing\} and Sheu, \{Jyh Horng\} and Sung, \{Ping Jyun\}",

note = "Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI.",

year = "2016",

month = jan,

doi = "10.3390/md14010012",

language = "英语",

volume = "14",

journal = "Marine Drugs",

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T1 - Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.

AU - Chang, Yu Chia

AU - Kuo, Liang Mou

AU - Hwang, Tsong Long

AU - Yeh, Jessica

AU - Wen, Zhi Hong

AU - Fang, Lee Shing

AU - Wu, Yang Chang

AU - Lin, Chan Shing

AU - Sheu, Jyh Horng

AU - Sung, Ping Jyun

PY - 2016/1

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N2 - Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

AB - Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

KW - Anti-inflammatory

KW - Cytotoxicity

KW - Elastase

KW - Gorgonian

KW - HSCs

KW - Pinnigorgia

KW - Secosterol

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/84955478513

U2 - 10.3390/md14010012

DO - 10.3390/md14010012

M3 - 文章

C2 - 26751457

AN - SCOPUS:84955478513

SN - 1660-3397

VL - 14

JO - Marine Drugs

JF - Marine Drugs

IS - 1

M1 - 12

ER -

Pinnisterols A-C, new 9,11-secosterols from a gorgonian Pinnigorgia sp.

Abstract

Bibliographical note

Keywords

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