Pinnisterols D-J, new 11-acetoxy-9,11-secosterols with a 1,4-quinone moiety from formosan gorgonian coral Pinnigorgia sp. (Gorgoniidae)

Yu Chia Chang; Tsong Long Hwang; Liang Mou Kuo; Ping Jyun Sung

doi:10.3390/md15010011

Pinnisterols D-J, new 11-acetoxy-9,11-secosterols with a 1,4-quinone moiety from formosan gorgonian coral Pinnigorgia sp. (Gorgoniidae)

Yu Chia Chang, Tsong Long Hwang, Liang Mou Kuo, Ping Jyun Sung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D-J (1-7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1-7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC₅₀ value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils.

Original language	English
Article number	11
Journal	Marine Drugs
Volume	15
Issue number	1
DOIs	https://doi.org/10.3390/md15010011
State	Published - 01 2017

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

9,11-secosterol
Anti-inflammatory
Cytotoxicity
Elastase
Gorgonian
Hepatic stellate cell line (HSC-T6)
Pinnigorgia
Superoxide anion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md15010011

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title = "Pinnisterols D-J, new 11-acetoxy-9,11-secosterols with a 1,4-quinone moiety from formosan gorgonian coral Pinnigorgia sp. (Gorgoniidae)",

abstract = "Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D-J (1-7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1-7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50 value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils.",

keywords = "9,11-secosterol, Anti-inflammatory, Cytotoxicity, Elastase, Gorgonian, Hepatic stellate cell line (HSC-T6), Pinnigorgia, Superoxide anion",

author = "Chang, {Yu Chia} and Hwang, {Tsong Long} and Kuo, {Liang Mou} and Sung, {Ping Jyun}",

note = "Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2017",

month = jan,

doi = "10.3390/md15010011",

language = "英语",

volume = "15",

journal = "Marine Drugs",

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publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Pinnisterols D-J, new 11-acetoxy-9,11-secosterols with a 1,4-quinone moiety from formosan gorgonian coral Pinnigorgia sp. (Gorgoniidae)

AU - Chang, Yu Chia

AU - Hwang, Tsong Long

AU - Kuo, Liang Mou

AU - Sung, Ping Jyun

PY - 2017/1

Y1 - 2017/1

N2 - Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D-J (1-7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1-7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50 value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils.

AB - Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D-J (1-7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1-7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50 value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils.

KW - 9,11-secosterol

KW - Anti-inflammatory

KW - Cytotoxicity

KW - Elastase

KW - Gorgonian

KW - Hepatic stellate cell line (HSC-T6)

KW - Pinnigorgia

KW - Superoxide anion

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U2 - 10.3390/md15010011

DO - 10.3390/md15010011

M3 - 文章

C2 - 28067822

AN - SCOPUS:85012911960

SN - 1660-3397

VL - 15

JO - Marine Drugs

JF - Marine Drugs

IS - 1

M1 - 11

ER -

Pinnisterols D-J, new 11-acetoxy-9,11-secosterols with a 1,4-quinone moiety from formosan gorgonian coral Pinnigorgia sp. (Gorgoniidae)

Abstract

Bibliographical note

Keywords

UN SDGs

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