Plasma-treated and collagen-coated plla nanofiber membrane for cartilage tissue engineering

J. P. Chen*, S. F. Lee, I. P. Chiang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Biodegradable nanofiber membranes from poly-L-lactic acid (PLLA) were prepared by electrospinning and used as a scaffold for cartilage tissue engineering. Operating parameters during the electrospinning process were studied in details in terms of fiber diameter and pore size of the membranes. The nanofiber membranes were characterized by SEM, FESEM, BET, AFM, and TEM. In order to improve cell attachment and growth, nanofibers were subjected to DC-pulsed oxygen plasma treatment, acrylic acid grafting, and collagen coating by covalent binding of collagen to carboxylic moieties of the polyacrylic acid. The bioactive scaffolds could be used for culture of chondrocyte with improved cell viability, proliferation, and differentiation.

Original languageEnglish
Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
EditorsM. Laudon, B. Romanowicz
Pages100-103
Number of pages4
StatePublished - 2005
Event2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States
Duration: 08 05 200512 05 2005

Publication series

Name2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Conference

Conference2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
Country/TerritoryUnited States
CityAnaheim, CA
Period08/05/0512/05/05

Keywords

  • Collagen
  • Electrospinning
  • Nanofibers
  • Plasma modification
  • Tissue engineering

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