TY - JOUR
T1 - Plasmapheresis as adjuvant therapy in Stevens-Johnson syndrome and hepatic encephalopathy
AU - Hung, Po Cheng
AU - Wang, Huei Shyong
AU - Hsia, Shao Hsuan
AU - Wong, Alex M.C.
PY - 2014/4
Y1 - 2014/4
N2 - Stevens-Johnson syndrome (SJS) is a severe idiosyncratic reaction, most commonly triggered by medications, which is characterized by fever and mucocutaneous lesions, leading to necrosis and sloughing of the epidermis. Aside from skin and mucosal manifestations, SJS may also compromise heart, liver, kidney, lung, and gastrointestinal tract. Although cholestatic liver disease has been reported to occur in SJS, hepatic encephalopathy (HE) as a delayed complication has never been reported. We report a 4-year-old female child with anticonvulsant-induced SJS complicated by HE who was completely cured with a combination of systemic corticosteroid, intravenous immunoglobulin (IVIG), and plasmapheresis therapy. We suggested that plasmapheresis may be used as an adjuvant therapy for SJS with HE.
AB - Stevens-Johnson syndrome (SJS) is a severe idiosyncratic reaction, most commonly triggered by medications, which is characterized by fever and mucocutaneous lesions, leading to necrosis and sloughing of the epidermis. Aside from skin and mucosal manifestations, SJS may also compromise heart, liver, kidney, lung, and gastrointestinal tract. Although cholestatic liver disease has been reported to occur in SJS, hepatic encephalopathy (HE) as a delayed complication has never been reported. We report a 4-year-old female child with anticonvulsant-induced SJS complicated by HE who was completely cured with a combination of systemic corticosteroid, intravenous immunoglobulin (IVIG), and plasmapheresis therapy. We suggested that plasmapheresis may be used as an adjuvant therapy for SJS with HE.
KW - Child
KW - Hepatic encephalopathy
KW - Plasmapheresis
KW - Stevens-Johnson
UR - http://www.scopus.com/inward/record.url?scp=84896138728&partnerID=8YFLogxK
U2 - 10.1016/j.braindev.2013.05.010
DO - 10.1016/j.braindev.2013.05.010
M3 - 文章
C2 - 23777679
AN - SCOPUS:84896138728
SN - 0387-7604
VL - 36
SP - 356
EP - 358
JO - Brain and Development
JF - Brain and Development
IS - 4
ER -