TY - JOUR
T1 - Platelet-related phenotypic patterns in hepatocellular carcinoma patients
AU - Carr, Brian I.
AU - Lin, Chih Yun
AU - Lu, Sheng Nan
PY - 2014/6
Y1 - 2014/6
N2 - Small hepatocellular carcinomas (HCCs) usually arise in cirrhosis, often with associated thrombocytopenia. Many patients with large HCCs have normal blood platelet counts. In this review, we compare parameter and phenotype patterns of patients with small (≤3 cm) and larger HCCs. A retrospective analysis was undertaken of a 4,139-patient HCC database to compare patient demographics, and liver and tumor characteristics associated with small and large HCCs, especially with respect to platelet counts. We found that patients with larger HCCs had more tumor nodules and portal vein thrombosis (PVT) positivity, and had higher blood alpha-fetoprotein (AFP), bilirubin, and platelet counts. In patients with larger tumors and normal platelets (43.7% of the cohort), tumors were larger and AFP levels were higher, with lower bilirubin and aspartate aminotransferase (AST) levels than in patients with larger tumors and thrombocytopenia (17.5%). A parsimonious multinomial regression model showed a high odds ratio for AFP and platelets for tumors > cm with PVT. We conclude that platelet levels are associated with distinct large HCC phenotypes.
AB - Small hepatocellular carcinomas (HCCs) usually arise in cirrhosis, often with associated thrombocytopenia. Many patients with large HCCs have normal blood platelet counts. In this review, we compare parameter and phenotype patterns of patients with small (≤3 cm) and larger HCCs. A retrospective analysis was undertaken of a 4,139-patient HCC database to compare patient demographics, and liver and tumor characteristics associated with small and large HCCs, especially with respect to platelet counts. We found that patients with larger HCCs had more tumor nodules and portal vein thrombosis (PVT) positivity, and had higher blood alpha-fetoprotein (AFP), bilirubin, and platelet counts. In patients with larger tumors and normal platelets (43.7% of the cohort), tumors were larger and AFP levels were higher, with lower bilirubin and aspartate aminotransferase (AST) levels than in patients with larger tumors and thrombocytopenia (17.5%). A parsimonious multinomial regression model showed a high odds ratio for AFP and platelets for tumors > cm with PVT. We conclude that platelet levels are associated with distinct large HCC phenotypes.
UR - http://www.scopus.com/inward/record.url?scp=84904213142&partnerID=8YFLogxK
U2 - 10.1053/j.seminoncol.2014.04.001
DO - 10.1053/j.seminoncol.2014.04.001
M3 - 文章
C2 - 25023358
AN - SCOPUS:84904213142
SN - 0093-7754
VL - 41
SP - 415
EP - 421
JO - Seminars in Oncology
JF - Seminars in Oncology
IS - 3
ER -