Abstract
During the regeneration of tissues and organs, growth factors (GFs) play a vital role by affecting cell behaviors. However, because of low half-life time and quick degradation of GFs, their stimulations on cells are relatively short and discontinuous. In our study, a releasing scaffold platform, consisting of polycaprolactone (PCL) nanofibers and vascular endothelial growth factor (VEGF)-encapsulated gelatin particles, has been developed to extend the influence of GFs on mesenchymal stem cells (MSCs) and endothelial cells (ECs). The results showed that this kind of scaffold could direct the differentiation of MSCs to ECs and maintain the stability of its tubular structure for an extended period of time, thus suggesting its potential application in vascular tissue engineering.
Original language | English |
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State | Published - 2018 |
Externally published | Yes |
Event | 2018 Society of Plastics Engineers Annual Technical Conference, ANTEC 2018 - Orlando, United States Duration: 07 05 2018 → 10 05 2018 |
Conference
Conference | 2018 Society of Plastics Engineers Annual Technical Conference, ANTEC 2018 |
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Country/Territory | United States |
City | Orlando |
Period | 07/05/18 → 10/05/18 |
Bibliographical note
Publisher Copyright:© 2018 Society of Plastics Engineers. All rights reserved.
Keywords
- Angiogenesis
- Endothelial differentiation
- Growth factor releasing
- Mesenchymal stem cells (MSCs)
- Nanofibers