Polycaprolactone nanofibers containing vascular endothelial growth factor-encapsulated gelatin particles enhance mesenchymal stem cell differentiation to endothelial cells and angiogenesis of endothelial cells

Yong Chao Jiang, Yi Yang Xu, An Huang, Yu Hui Qiao, Xiao Feng Wang, Qian Li, Lih Sheng Turng*

*Corresponding author for this work

Research output: Contribution to conferenceConference Paperpeer-review

Abstract

During the regeneration of tissues and organs, growth factors (GFs) play a vital role by affecting cell behaviors. However, because of low half-life time and quick degradation of GFs, their stimulations on cells are relatively short and discontinuous. In our study, a releasing scaffold platform, consisting of polycaprolactone (PCL) nanofibers and vascular endothelial growth factor (VEGF)-encapsulated gelatin particles, has been developed to extend the influence of GFs on mesenchymal stem cells (MSCs) and endothelial cells (ECs). The results showed that this kind of scaffold could direct the differentiation of MSCs to ECs and maintain the stability of its tubular structure for an extended period of time, thus suggesting its potential application in vascular tissue engineering.

Original languageEnglish
StatePublished - 2018
Externally publishedYes
Event2018 Society of Plastics Engineers Annual Technical Conference, ANTEC 2018 - Orlando, United States
Duration: 07 05 201810 05 2018

Conference

Conference2018 Society of Plastics Engineers Annual Technical Conference, ANTEC 2018
Country/TerritoryUnited States
CityOrlando
Period07/05/1810/05/18

Bibliographical note

Publisher Copyright:
© 2018 Society of Plastics Engineers. All rights reserved.

Keywords

  • Angiogenesis
  • Endothelial differentiation
  • Growth factor releasing
  • Mesenchymal stem cells (MSCs)
  • Nanofibers

Fingerprint

Dive into the research topics of 'Polycaprolactone nanofibers containing vascular endothelial growth factor-encapsulated gelatin particles enhance mesenchymal stem cell differentiation to endothelial cells and angiogenesis of endothelial cells'. Together they form a unique fingerprint.

Cite this