Polymorphisms of ACMSD - TMEM163, MCCC1, and BCKDK - STX1B Are Not Associated with Parkinson's Disease in Taiwan

Kuo Hsuan Chang; Chiung Mei Chen; Yi Chun Chen; Hon Chung Fung; Yih Ru Wu

doi:10.1155/2019/3489638

Polymorphisms of ACMSD - TMEM163, MCCC1, and BCKDK - STX1B Are Not Associated with Parkinson's Disease in Taiwan

Kuo Hsuan Chang, Chiung Mei Chen, Yi Chun Chen, Hon Chung Fung, Yih Ru Wu^*

^*Corresponding author for this work

School of Medicine

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

8 Scopus citations

Abstract

Previous genome-wide association studies in Caucasian populations suggest that genetic loci in amino acid catabolism may be associated with Parkinson's disease (PD). However, these genetic disease associations were limitedly reported in Asian populations. Herein, we investigated the effect of top three PD-associated genetic variants related to amino acid catabolism in Caucasians listed on the top risk loci identified by meta-analysis of genome-wide association studies in PDGene database, including aminocarboxymuconate-semialdehyde decarboxylase- (ACMSD-) transmembrane protein 163 (TMEM163) rs6430538, methylcrotonyl-CoA carboxylase 1 (MCCC1) rs12637471, and branched-chain ketoacid dehydrogenase kinase- (BCKDK-) syntaxin 1B (STX1B) rs14235, by genotyping 599 Taiwanese patients with PD and 598 age-matched control subjects. PD patients demonstrate similar allelic and genotypic frequencies in all tested genetic variants. These ethnic discrepancies of genetic variants suggest a distinct genetic background of amino acid catabolism between Taiwanese and Caucasian PD patients.

Original language	English
Article number	3489638
Journal	Parkinson's Disease
Volume	2019
DOIs	https://doi.org/10.1155/2019/3489638
State	Published - 2019

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© 2019 Kuo-Hsuan Chang et al.

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title = "Polymorphisms of ACMSD - TMEM163, MCCC1, and BCKDK - STX1B Are Not Associated with Parkinson's Disease in Taiwan",

abstract = "Previous genome-wide association studies in Caucasian populations suggest that genetic loci in amino acid catabolism may be associated with Parkinson's disease (PD). However, these genetic disease associations were limitedly reported in Asian populations. Herein, we investigated the effect of top three PD-associated genetic variants related to amino acid catabolism in Caucasians listed on the top risk loci identified by meta-analysis of genome-wide association studies in PDGene database, including aminocarboxymuconate-semialdehyde decarboxylase- (ACMSD-) transmembrane protein 163 (TMEM163) rs6430538, methylcrotonyl-CoA carboxylase 1 (MCCC1) rs12637471, and branched-chain ketoacid dehydrogenase kinase- (BCKDK-) syntaxin 1B (STX1B) rs14235, by genotyping 599 Taiwanese patients with PD and 598 age-matched control subjects. PD patients demonstrate similar allelic and genotypic frequencies in all tested genetic variants. These ethnic discrepancies of genetic variants suggest a distinct genetic background of amino acid catabolism between Taiwanese and Caucasian PD patients.",

author = "Chang, {Kuo Hsuan} and Chen, {Chiung Mei} and Chen, {Yi Chun} and Fung, {Hon Chung} and Wu, {Yih Ru}",

note = "Publisher Copyright: {\textcopyright} 2019 Kuo-Hsuan Chang et al.",

year = "2019",

doi = "10.1155/2019/3489638",

language = "英语",

volume = "2019",

journal = "Parkinson's Disease",

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T1 - Polymorphisms of ACMSD - TMEM163, MCCC1, and BCKDK - STX1B Are Not Associated with Parkinson's Disease in Taiwan

AU - Chang, Kuo Hsuan

AU - Chen, Chiung Mei

AU - Chen, Yi Chun

AU - Fung, Hon Chung

AU - Wu, Yih Ru

PY - 2019

Y1 - 2019

N2 - Previous genome-wide association studies in Caucasian populations suggest that genetic loci in amino acid catabolism may be associated with Parkinson's disease (PD). However, these genetic disease associations were limitedly reported in Asian populations. Herein, we investigated the effect of top three PD-associated genetic variants related to amino acid catabolism in Caucasians listed on the top risk loci identified by meta-analysis of genome-wide association studies in PDGene database, including aminocarboxymuconate-semialdehyde decarboxylase- (ACMSD-) transmembrane protein 163 (TMEM163) rs6430538, methylcrotonyl-CoA carboxylase 1 (MCCC1) rs12637471, and branched-chain ketoacid dehydrogenase kinase- (BCKDK-) syntaxin 1B (STX1B) rs14235, by genotyping 599 Taiwanese patients with PD and 598 age-matched control subjects. PD patients demonstrate similar allelic and genotypic frequencies in all tested genetic variants. These ethnic discrepancies of genetic variants suggest a distinct genetic background of amino acid catabolism between Taiwanese and Caucasian PD patients.

AB - Previous genome-wide association studies in Caucasian populations suggest that genetic loci in amino acid catabolism may be associated with Parkinson's disease (PD). However, these genetic disease associations were limitedly reported in Asian populations. Herein, we investigated the effect of top three PD-associated genetic variants related to amino acid catabolism in Caucasians listed on the top risk loci identified by meta-analysis of genome-wide association studies in PDGene database, including aminocarboxymuconate-semialdehyde decarboxylase- (ACMSD-) transmembrane protein 163 (TMEM163) rs6430538, methylcrotonyl-CoA carboxylase 1 (MCCC1) rs12637471, and branched-chain ketoacid dehydrogenase kinase- (BCKDK-) syntaxin 1B (STX1B) rs14235, by genotyping 599 Taiwanese patients with PD and 598 age-matched control subjects. PD patients demonstrate similar allelic and genotypic frequencies in all tested genetic variants. These ethnic discrepancies of genetic variants suggest a distinct genetic background of amino acid catabolism between Taiwanese and Caucasian PD patients.

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DO - 10.1155/2019/3489638

M3 - 文章

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SN - 2042-0080

VL - 2019

JO - Parkinson's Disease

JF - Parkinson's Disease

M1 - 3489638

ER -

Polymorphisms of ACMSD - TMEM163, MCCC1, and BCKDK - STX1B Are Not Associated with Parkinson's Disease in Taiwan

Abstract

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