Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in illicit drug use and drug-related psychiatric disorders

Chih Ken Chen; Shih Ku Lin; Shu Chuan Chiang; Lien Wen Su; Liang Jen Wang

doi:10.3109/10826084.2014.901391

Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in illicit drug use and drug-related psychiatric disorders

Chih Ken Chen
, Shih Ku Lin
, Shu Chuan Chiang
, Lien Wen Su
, Liang Jen Wang^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

10 Scopus citations

Abstract

To investigate the involvement of COMT Val158Met and DAT1 3′-UTR VNTR genotypes in the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 substance users and 386 normal controls were recruited from Northern Taiwan. Substance users and normal controls significantly differed in allele frequencies of COMT Val158Met (p = 0.039) but not in allele frequencies of DAT1 3′-UTR VNTR (p = 0.879). However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3′-UTR VNTR were associated with DIP. The findings should be confirmed in further studies of a larger sample size and a more homogenous patient group.

Original language	English
Pages (from-to)	1385-1391
Number of pages	7
Journal	Substance Use and Misuse
Volume	49
Issue number	11
DOIs	https://doi.org/10.3109/10826084.2014.901391
State	Published - 09 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COMT
DAT1
Dopamine
Genotype
Mood disorder
Psychosis
Substance use
Suicide

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10.3109/10826084.2014.901391

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title = "Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in illicit drug use and drug-related psychiatric disorders",

abstract = "To investigate the involvement of COMT Val158Met and DAT1 3′-UTR VNTR genotypes in the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 substance users and 386 normal controls were recruited from Northern Taiwan. Substance users and normal controls significantly differed in allele frequencies of COMT Val158Met (p = 0.039) but not in allele frequencies of DAT1 3′-UTR VNTR (p = 0.879). However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3′-UTR VNTR were associated with DIP. The findings should be confirmed in further studies of a larger sample size and a more homogenous patient group.",

keywords = "COMT, DAT1, Dopamine, Genotype, Mood disorder, Psychosis, Substance use, Suicide",

author = "Chen, \{Chih Ken\} and Lin, \{Shih Ku\} and Chiang, \{Shu Chuan\} and Su, \{Lien Wen\} and Wang, \{Liang Jen\}",

year = "2014",

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doi = "10.3109/10826084.2014.901391",

language = "英语",

volume = "49",

pages = "1385--1391",

journal = "Substance Use and Misuse",

issn = "1082-6084",

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}

TY - JOUR

T1 - Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in illicit drug use and drug-related psychiatric disorders

AU - Chen, Chih Ken

AU - Lin, Shih Ku

AU - Chiang, Shu Chuan

AU - Su, Lien Wen

AU - Wang, Liang Jen

PY - 2014/9

Y1 - 2014/9

N2 - To investigate the involvement of COMT Val158Met and DAT1 3′-UTR VNTR genotypes in the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 substance users and 386 normal controls were recruited from Northern Taiwan. Substance users and normal controls significantly differed in allele frequencies of COMT Val158Met (p = 0.039) but not in allele frequencies of DAT1 3′-UTR VNTR (p = 0.879). However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3′-UTR VNTR were associated with DIP. The findings should be confirmed in further studies of a larger sample size and a more homogenous patient group.

AB - To investigate the involvement of COMT Val158Met and DAT1 3′-UTR VNTR genotypes in the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 substance users and 386 normal controls were recruited from Northern Taiwan. Substance users and normal controls significantly differed in allele frequencies of COMT Val158Met (p = 0.039) but not in allele frequencies of DAT1 3′-UTR VNTR (p = 0.879). However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3′-UTR VNTR were associated with DIP. The findings should be confirmed in further studies of a larger sample size and a more homogenous patient group.

KW - COMT

KW - DAT1

KW - Dopamine

KW - Genotype

KW - Mood disorder

KW - Psychosis

KW - Substance use

KW - Suicide

UR - https://www.scopus.com/pages/publications/84905040233

U2 - 10.3109/10826084.2014.901391

DO - 10.3109/10826084.2014.901391

M3 - 文章

C2 - 24708432

AN - SCOPUS:84905040233

SN - 1082-6084

VL - 49

SP - 1385

EP - 1391

JO - Substance Use and Misuse

JF - Substance Use and Misuse

IS - 11

ER -

Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in illicit drug use and drug-related psychiatric disorders

Abstract

UN SDGs

Keywords

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