Population-based family case-control proband study on familial aggregation of metabolic syndrome: Finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS no. 5)

Yueh Hsia Chiu, Wen Yuan Lin, Po En Wang, Yao Der Chen, Ting Ting Wang, Jane Warwick, Tony Hsiu Hsi Chen*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations

Abstract

A population-based case-control proband study was undertaken to elucidate familial aggregation, independent environmental factors, and the interaction between them. A total of 7308 metabolic syndrome (MET-S) cases were identified from the Keelung community-based integrated screening programme between 1999 and 2002. The study has a case-control/family sampling design. A total of 1417 case probands were randomly selected from 3225 metabolic syndrome cases and the corresponding 2458 controls selected from 16,519 subjects without metabolic syndrome by matching on sex, age (±3 years) and place of residence. The generalized estimation equation model was used to estimate odds ratios and corresponding 95% confidence intervals. The risk for having metabolic syndrome among family members for cases versus control probands was 1.56-fold (1.29-1.89) after controlling for significant environmental factors. Higher risk of metabolic syndrome was found in parents than spouse. Low education against high education had 2.06-fold (1.36-3.13) risk for metabolic syndrome. Betel quid chewing was positively associated with the risk of MET-S, with 1.99-fold (1.13-3.53) risk for 1-9 pieces and 1.76-fold (0.96-3.23) risk for ≥10 pieces compared with non-chewer. Moderate and high intensity of non-occupational exercise led to 21.0% (OR = 0.79 (0.63-0.98)) and 26.0% (OR = 0.74 (0.59-0.94)) reduction in the risk for metabolic syndrome, respectively. The frequent consumption of vegetable reduced 24.0% (OR = 0.76 (0.62-0.92)) risk for MET-S. The frequent consumption of coffee was associated the increased risk for metabolic syndrome (OR = 1.32 (1.07-1.64)). The present study confirmed the risk of metabolic syndrome not only has the tendency towards familial aggregation but is affected by independent effect of environmental or individual correlates.

Original languageEnglish
Pages (from-to)348-356
Number of pages9
JournalDiabetes Research and Clinical Practice
Volume75
Issue number3
DOIs
StatePublished - 03 2007
Externally publishedYes

Keywords

  • Environmental factors
  • Familial aggregation
  • Family case-control proband study
  • Metabolic syndrome

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