Postreplicational formation and repair of DNA double-strand breaks in UV-irradiated Escherichia coli uvrB cells

Tzu chien V. Wang; Kendric C. Smith

doi:10.1016/0167-8817(86)90007-6

Postreplicational formation and repair of DNA double-strand breaks in UV-irradiated Escherichia coli uvrB cells

Tzu chien V. Wang^*
, Kendric C. Smith

^*Corresponding author for this work

Stanford University

Research output: Contribution to journal › Journal Article › peer-review

50 Scopus citations

Abstract

The number of DNA double-strand breaks formed in UV-irradiated uvrB rec F recB cells correlates with the number of unrepaired DNA daughter-strand gaps, and is dependent on DNA synthesis after UV-irradiation. These results are consistent with the model that the DNA double-strand breaks that are produced in UV-irradiated excision-deficient cells occur as the results of breaks in the parental DNA opposite unrepaired DNA daughter-strand gaps. By employing a temperature-sensitive recA200 mutation, breaks. Possible mechanisms for the postreplication repair of DNA double-strand breaks are discussed.

Original language	English
Pages (from-to)	39-44
Number of pages	6
Journal	Mutation Research DNA Repair Reports
Volume	165
Issue number	1
DOIs	https://doi.org/10.1016/0167-8817(86)90007-6
State	Published - 01 1986
Externally published	Yes

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title = "Postreplicational formation and repair of DNA double-strand breaks in UV-irradiated Escherichia coli uvrB cells",

abstract = "The number of DNA double-strand breaks formed in UV-irradiated uvrB rec F recB cells correlates with the number of unrepaired DNA daughter-strand gaps, and is dependent on DNA synthesis after UV-irradiation. These results are consistent with the model that the DNA double-strand breaks that are produced in UV-irradiated excision-deficient cells occur as the results of breaks in the parental DNA opposite unrepaired DNA daughter-strand gaps. By employing a temperature-sensitive recA200 mutation, breaks. Possible mechanisms for the postreplication repair of DNA double-strand breaks are discussed.",

author = "Wang, \{Tzu chien V.\} and Smith, \{Kendric C.\}",

year = "1986",

month = jan,

doi = "10.1016/0167-8817(86)90007-6",

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volume = "165",

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AU - Wang, Tzu chien V.

AU - Smith, Kendric C.

PY - 1986/1

Y1 - 1986/1

N2 - The number of DNA double-strand breaks formed in UV-irradiated uvrB rec F recB cells correlates with the number of unrepaired DNA daughter-strand gaps, and is dependent on DNA synthesis after UV-irradiation. These results are consistent with the model that the DNA double-strand breaks that are produced in UV-irradiated excision-deficient cells occur as the results of breaks in the parental DNA opposite unrepaired DNA daughter-strand gaps. By employing a temperature-sensitive recA200 mutation, breaks. Possible mechanisms for the postreplication repair of DNA double-strand breaks are discussed.

AB - The number of DNA double-strand breaks formed in UV-irradiated uvrB rec F recB cells correlates with the number of unrepaired DNA daughter-strand gaps, and is dependent on DNA synthesis after UV-irradiation. These results are consistent with the model that the DNA double-strand breaks that are produced in UV-irradiated excision-deficient cells occur as the results of breaks in the parental DNA opposite unrepaired DNA daughter-strand gaps. By employing a temperature-sensitive recA200 mutation, breaks. Possible mechanisms for the postreplication repair of DNA double-strand breaks are discussed.

UR - https://www.scopus.com/pages/publications/1542674947

U2 - 10.1016/0167-8817(86)90007-6

DO - 10.1016/0167-8817(86)90007-6

M3 - 文章

C2 - 3510373

AN - SCOPUS:1542674947

SN - 0167-8817

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SP - 39

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JO - Mutation Research DNA Repair Reports

JF - Mutation Research DNA Repair Reports

IS - 1

ER -

Postreplicational formation and repair of DNA double-strand breaks in UV-irradiated Escherichia coli uvrB cells

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