Potential role of the mannose receptor in antigen transport

Luisa Martínez-Pomares; Siamon Gordon

doi:10.1016/S0165-2478(98)00117-5

Potential role of the mannose receptor in antigen transport

Luisa Martínez-Pomares^*, Siamon Gordon

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Journal Article › peer-review

25 Scopus citations

Abstract

Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport.

Original language	English
Pages (from-to)	9-13
Number of pages	5
Journal	Immunology Letters
Volume	65
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-2478(98)00117-5
State	Published - 01 01 1999
Externally published	Yes

Keywords

Antigen presentation
Macrophages
Mannose receptor
Mouse
Secondary lymphoid organs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0165-2478(98)00117-5

Cite this

@article{66dbadd9d9e147dead2843d42c300d33,

title = "Potential role of the mannose receptor in antigen transport",

abstract = "Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport.",

keywords = "Antigen presentation, Macrophages, Mannose receptor, Mouse, Secondary lymphoid organs",

author = "Luisa Mart{\'i}nez-Pomares and Siamon Gordon",

year = "1999",

month = jan,

day = "1",

doi = "10.1016/S0165-2478(98)00117-5",

language = "英语",

volume = "65",

pages = "9--13",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Potential role of the mannose receptor in antigen transport

AU - Martínez-Pomares, Luisa

AU - Gordon, Siamon

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport.

AB - Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport.

KW - Antigen presentation

KW - Macrophages

KW - Mannose receptor

KW - Mouse

KW - Secondary lymphoid organs

UR - https://www.scopus.com/pages/publications/0346593250

U2 - 10.1016/S0165-2478(98)00117-5

DO - 10.1016/S0165-2478(98)00117-5

M3 - 文章

C2 - 10065620

AN - SCOPUS:0346593250

SN - 0165-2478

VL - 65

SP - 9

EP - 13

JO - Immunology Letters

JF - Immunology Letters

IS - 1-2

ER -

Potential role of the mannose receptor in antigen transport

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this